Laboratory Research Technician or Specialist, Radiation Oncology

Job Summary

We are currently looking for an enthusiastic, scientifically curious researcher to work in the laboratory of Dr. Deepak Nijhawan, Professor, Vice Chair of Research and Chief of Molecular Medicine in the Department of Radiation Oncology. The research program in the Nijhawan lab involves a collaborative approach to understand the mechanism of action for small molecules with interesting biologic activity, identify their molecular targets, and explore the therapeutic potential of novel compounds.

The lab mission is focused on translational opportunities relevant to human disease, with a keen interest in identifying novel cancer therapeutics. (Use the "Apply for this Job" box below).-lab

We are seeking highly organized and proactive individuals to join our multi‑disciplinary team. Positions are available in several areas including focuses on molecular biology and biochemistry or on in‑vivo studies to support the preclinical development of novel compounds. The ideal candidate would be self‑motivated and possess strong initiative to problem‑solve and to troubleshoot experimental or technical issues. It is essential that the candidate pay close attention to details and be able to keep careful records of experiments and results.

Strong organizational skills, prioritization skills, and time‑management skills are a must. It will also be important for the candidate to work efficiently and be able to adapt to changing priorities. Candidates who are eager to learn and be part of a fast‑paced research environment will be given the strongest consideration.

• PPO medical plan, available day one at no cost for full‑time employee‑only coverage
• Paid Time Off, available day one
• Retirement Programs through the Teacher Retirement System of Texas (TRS)
• Paid Parental Leave Benefit
• Wellness programs
• Tuition Reimbursement
• Public Service Loan Forgiveness (PSLF) Qualified Employer

Bachelor’s Degree with major coursework in field of assignment and no experience.

No experience required with Bachelor’s Degree.

• Design and perform molecular biology experiments, including plasmid construction, cloning, and mutagenesis.
• Generate and characterize CRISPR‑edited cell lines for functional studies.
• Express and purify recombinant proteins using affinity and size‑exclusion chromatography.
• Perform biochemical and biophysical assays to assess protein activity, stability, and interactions.
• Conduct probe binding and fluorescence‑based assays (e.g., FP, FRET).
• Maintain accurate lab records, prepare reagents, assist with data analysis, and be open to regularly presenting the findings in lab meetings.
• Design, plan, and execute in‑vivo studies to evaluate novel compounds in preclinical mouse experiments, including pharmacokinetic studies, pharmacodynamic studies, and efficacy studies.
• Monitor and analyze in‑vivo studies including but not limited to tumor size, animal health condition, in‑vivo imaging, and flow cytometry analysis of tissues.
• Administer daily drug treatments to mice and record dosing.
• Assist with the maintenance, care, breeding and genomic screening of mice in laboratory mouse colonies.
• Tissue culture of mammalian cell lines and execution of standard in‑vitro molecular and biochemical assays.

Security:
This position is security‑sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.

EEO: UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.