Senior Research Associate, In Vivo Pharmacology

Signify Bio is a biotechnology company transforming the development of in situ protein therapeutics by leveraging the human body’s natural ability to produce proteins. Guided by its mission to create personalized medicines for all, Signify combines the precision of signal peptide engineered control with the speed and versatility of mRNA encoded design. The company’s SEND platform and iPhos lipid nanoparticles enable targeted and localized delivery of therapeutic proteins, addressing significant unmet needs across various diseases.

Through innovative science, Signify Bio is committed to advancing solutions that make a meaningful difference for patients worldwide.

At Signify, we bring together collaborative teams, innovative science, and a shared commitment to addressing meaningful unmet patient needs. Employees have the opportunity to work across disciplines, contribute to cutting-edge therapeutic programs, and help translate scientific discoveries into potential medicines. We value scientific rigor, open communication, curiosity, and teamwork, and we encourage every team member to contribute ideas, take ownership, and grow alongside the organization.

We are adding an experienced Senior Research Associate to our Translational Sciences team to develop and execute in vivo pharmacology and molecular biology studies. Primary responsibility will be conducting in vivo studies to identify and progress lead formulations towards the clinic.

• Design and perform in vivo pharmacology studies in rodent models, including dosing (IV, IP, SC, IM) and tissue collection in mice and rats
• Collect and process biological samples (blood, liver, muscle, and other organs) for downstream analysis
• Design, perform and analyze molecular biology experiments, including ELISA, WB, QPCR
• Maintain accurate records of experiments, protocols, and data in electronic lab notebooks (ELN) to support PK/PD, efficacy, and safety studies
• Collaborate daily with cross-functional teams, including Biology and Formulations
• Ensure compliance with IACUC protocols and maintain high standards of animal welfare

• BS in Life Sciences, including Pharmacology, Immunology, Biology, or a related field with 5-7years of in vivo research experience (industry experience preferred), OR
• MS in relevant Life Sciences discipline with 3-5 years of related research experience

• Hands-on experience with rodent (rat and mouse) handling, dosing techniques, in-life and terminal blood collection, and necropsy
• Proficiency with i.v, s.c, and i.m. injections and blood collection by various methods
• Proficiency with molecular biology techniques and methods, including ELISA, WB, QPCR
• Proficient in Word, Excel, PowerPoint, and Graph Pad Prism

This lab-based position requires the ability to stand for extended periods as well as occasional need to reach, bend, stoop, and climb stairs. Working with rodent cages may require working in an uncomfortable physical position briefly in order to change or clean cages. Lifting requirement may occasionally be up to approximately 25 lbs. Pushing/pulling carts or cage racks may be required.

Manual dexterity and fine motor skills are needed to handle small animals.

Position involves regular exposure to biological materials such as animal allergens and requires regular use of Personal Protective Equipment (gown, mask, gloves) and strict compliance with Environmental Health & Safety guidelines.

Signify Bio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.