Scale-Up Engineer

## Scale-Up Engineer Apply locations:
Decatur, ILtime type:
Full time posted on:
Posted 2 Days Agojob requisition :
JREQ
6919#
** About IPROOF
**** Join the Future of Biomanufacturing
** At iPROOF, we are building a state-of-the-art hub for bioproducts innovation. We offer dynamic career opportunities for scientific and technical professionals who are driven to scale the future of precision fermentation.

We combine the agility of a biotech startup with the stability of an industry leader. As a part of the iPROOF team, you will help advance critical innovations in an inclusive environment that values curiosity, embraces diversity of thought, and actively challenges the status quo.

Because we believe in investing in our people, iPROOF offers a highly competitive benefits package, including comprehensive healthcare, dental and vision, retirement plans with an employer contribution, and paid parental leave.#
** About the Role
** The Scale-Up Engineer is responsible for transferring fermentation processes from laboratory and pilot scales into demonstration environments. This role serves as the technical bridge between R&D, process development, manufacturing, quality, and engineering teams to ensure successful scale-up, robust process performance, and efficient commercialization. The engineer will lead process characterization, scale-up studies, technology transfer activities, batch execution support, troubleshooting, and continuous improvement initiatives for microbial, fungal, yeast, and/or heterotrophic algae fermentation and downstream processes.
***
* Key responsibilities:

Process Engineer
****** Technology Transfer:
** Lead technology transfer projects from bench, pilot, or external development organizations into the iPROOF facility.  Develop and maintain technology transfer packages including; process descriptions, batch records, SOPs, process flow diagrams, material balances, and control strategies.  This role will help  coordinate knowledge transfer between iPROOF and customers and facilitate technical risk assessments and transfer readiness reviews.
** Fermentation Development and Scale-Up:
** Scale fermentation processes through pilot and demonstration scales to de-risk the technology.  Evaluate critical scale-up parameters including oxygen transfer (kLa), power input (P/V), mixing time, gas flow rates, heat transfer requirements, and feed strategies. Support seed train development and scale progression strategies. Design and execute experiments for media optimization, feeding strategies, and induction strategies, Apply statistical and data-driven methods to improve process performance.

Identify opportunities to improve throughput, yield, and manufacturing economics.
** Process Development and Optimization:
** Recommend unit operations needed and their order to obtain desired product. Design and execute unit-operations-specific experiments for throughput and efficiency. Apply statistical and data-driven methods to improve process performance and identify opportunities.
** Manufacturing Support:
** Provide on-floor technical support during fermentation campaigns.  Troubleshoot issues related to growth performance, titer, yield, productivity, contamination events, and process control. Analyze process data and recommend corrective actions. Support deviation investigations, root-cause analyses (RCAs), and corrective and preventive actions (CAPAs).
** Engineering and Equipment Integration:
** Collaborate with engineering teams on utility requirements, piping and instrumentation, CIP/SIP systems, and process controls. Support FAT, SAT, commissioning, qualification, and startup activities. Assist in equipment sizing and process modeling.
** Documentation and Compliance:
** Author and review master batch records, process descriptions, technical reports, validation protocols, and technology transfer documents.  Ensure compliance with applicable food, feed, industrial biotech, or regulatory standards.  Maintain accurate project documentation and transfer records.
** Project Management:
** Manage multiple technology transfer and scale-up projects simultaneously. Track timelines, budgets, risks, and deliverables. Interface directly with customers, strategic partners, and commercial stakeholders. Present project progress and technical findings to management.#
** About You
**** Knowledge
* ** General Chemistry
* Basic mathematical and physics principals
* Unit operation knowledge (fermentation, filtration, spray drying)
* • Safety best practices in a manufacturing or pilot/demo environment
* Biochemical engineering principles
* Quality/food safety knowledge
* Microsoft Office (Excel specific)
* Statistical analysis, including multivariate data analysis
* Understanding of process flows
** Skills
* ** Organization skills
* Time management & prioritization
* Excellent written and verbal communications
* Critical thinking
* Problem solving
* Teamwork* Project Management
* Maintains regulatory and technical awareness
* Ability to coordinate efforts of others
**…