Postgraduate Scholar - Seibold​/Moore Lab

Summary

The Seibold and Moore Laboratories are seeking a passionate and highly motivated Postgraduate Scholar to join our cutting‑edge, NIH‑funded research team. Our laboratories bring together an interdisciplinary group of experts in cell biology, skin and molecular biology, alongside experts in computational biology, bioinformatics, and statistical genetics. Our research focuses on unraveling the complex pathobiological mechanisms underlying atopic dermatitis, food allergy, asthma, and other allergic diseases.

The goal of our work is to identify and characterize pathobiological subtypes (i.e., endotypes) of allergic disease, and to determine the genetic, environmental, and immunological factors that drive disease development, progression, and treatment response. We have an exciting postdoctoral position available for a researcher to lead and conduct innovative investigations of how different types of skin pathobiology (i.e., endotypes) present in early life underlie the development of atopic dermatitis, and how this early life skin dysfunction subsequently leads to the development of other allergic diseases, including food allergy, allergic rhinitis and asthma.

The Postgraduate Research Scholar is a temporary, defined period of mentored advanced training. Postgraduate Research Scholars will focus on enhancing their professional skills and research independence under the mentorship of a Principal Investigator. The training program length is a maximum of five years.

• Perform transcriptomic profiling of longitudinal skin samples collected from a multi-center birth cohort study to determine inflammatory endotypes of atopic dermatitis in infancy and whether these patterns of dysregulation contribute to the development of food allergy in infancy.
• Identify common patterns of allergic disease development in early life and describe the differences in molecular and cellular development of the skin that underlie the atopic march and other patterns of allergic disease development and resolution.
• Use whole genome- and RNA‑seq data to identify eQTLs that influence early life skin expression and longitudinal skin development among allergic disease groups.

• Perform all phases of experimental investigations, including planning, developing, operating, recording, collaborating, and reporting of major projects.
• Collaborate with Principal Investigators and senior researchers in the progress of major research projects.
• Provide guidance to laboratory staff in one or more laboratory areas, including technicians, support, and auxiliary staff. Serve as the technical advisor on complex analyses utilizing highly sophisticated techniques.
• Review quality control of new or modified laboratory techniques that affect any part of major projects.
• Perform routine and non-routine tests leading to the successful completion of developed experiments and follow all age‑specific guidelines.

• Perform as a back‑up to staff absences and vacancies, as necessary.

• Accountability:
  Accepts full responsibility for self and contribution as a team member; displays honesty and truthfulness; confronts problems quickly; displays a strong commitment to organizational success and inspires others to commit to goals; demonstrates a commitment to National Jewish Health.
• Laboratory Knowledge:
  Demonstrates and understands laboratory testing and methodology.
• Decision Quality:
  Makes good decisions based upon a mixture of analysis, wisdom, experience, and judgement. Sought out by others for advice and solutions.
• Adaptability:
  Maintains effectiveness in the midst of changing work responsibilities or environment, requirement ambiguity, or stress.
• Problem Solving:
  Uses issue identification, data relation and comparison, pattern recognition, and information gathering to create analyses and make recommendations.
• Informing/Communicating:
  Conveys ideas, responses, or instructions effectively, appropriately, and persuasively through writing or speech.
• Professional Relationships:
  Interacts with others in a constructive, positive, and respectful manner, regardless of individual differences. Assists team members…