Postdoctoral Fellow - Diabetes and Cancer Metabolism Research

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we are changing lives and making a real difference in the fight against cancer, diabetes, and other life‑threatening illnesses. Our dedicated faculty and staff are driven by a common mission: contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting‑edge research.

A postdoctoral position is open in the laboratory of Yingfeng Deng in the Department of Diabetes and Cancer Metabolism. The Deng laboratory studies the homeostasis of uridine and its role in metabolism, providing a new angle for understanding the pathophysiology of obesity, diabetes, and cancer. Work in the lab utilizes genetically engineered mouse models and in vitro systems with state‑of‑the‑art surgical, genetic, cellular, biochemical, imaging, and metabolic flux approaches.

The laboratory focuses on three areas:
1) the role of uridine in the progression of obesity and diabetes;
2) the physiology of uridine in bile and nutrient absorption; and
3) the regulation of uridine homeostasis by ER stress and its relevance to breast cancer.

Conduct independent research to study the molecular, cellular, and metabolic mechanisms leading to obesity, diabetes, and cancer. Design, perform, and analyze experiments using mouse models and in vitro systems; interpret results in the context of uridine metabolism and disease pathophysiology. Collaborate with lab members and present findings at scientific meetings and in publications.

• Ph.D. and/or M.D. degree in life or biomedical sciences or a related discipline is required.
• Experience in basic molecular biology skills.
• Experience in animal models and lipid metabolism.
• Experience in metabolomics and liver physiology.

To apply, please attach a cover letter describing your past training and research interests, a detailed CV, and contact information for three referees.

City of Hope is an equal opportunity employer.

To learn more about our comprehensive benefits, please . For a complete list of publications, visit https://(Use the "Apply for this Job" box below)..