Staff Scientist - Integrative Genomics Core

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life‑threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting‑edge research.

We are seeking an experienced and highly motivated Staff Scientist to join the Integrative Genomics Core. You will provide scientific leadership in the development, optimization, and execution of advanced genomics workflows. You will work closely with investigators to design experiments, implement new technologies, and ensure delivery of high‑quality sequencing data. You will also contribute to the strategic growth of the core by evaluating and deploying emerging genomics platforms and methodologies.

The Integrative Genomics Core provides comprehensive genomics services to support cutting‑edge biomedical research. Leveraging advanced platforms such as Illumina, Pac Bio, Nanopore, and 10x Genomics, the core enables a broad range of genomic and epigenomic applications. These technologies empower investigators to explore complex biological systems, from cancer genomics to translational and precision medicine studies, within a highly collaborative, service‑oriented environment.

• Provide design and consultation on genomic approaches with investigators, including study design, sample requirements, and technology selection
• Complete complex genomics workflows such as bulk, single‑cell, and long‑read sequencing applications
• Develop, optimize, and update current protocols for Illumina, Pac Bio, Nanopore, and 10x Genomics platforms
• Evaluate and implement emerging technologies to expand core capabilities
• Ensure quality control standards and best practices across all stages of sample processing and sequencing
• Communicate results to investigators; collaborate with bioinformatics teams on data analysis as needed
• Assist with grant applications, methods development, and collaborative publications where appropriate
• Train, mentor, and provide technical guidance to research staff and junior personnel

• Ph.D. in Genomics, Molecular Biology, Genetics, or a related field
• Minimum 3‑5 years’ experience in genomics or sequencing technologies
• Extensive hands‑on experience across multiple sequencing platforms, including Illumina, Pac Bio, and 10x Genomics
• Expertise in library preparation for a variety of applications (RNA‑seq, DNA‑seq, ATAC‑seq, ChIP‑seq/CUT & RUN, methylation assays, and long‑read sequencing); experience with single‑cell and/or spatial genomics workflows (e.g., 10x Genomics Chromium, Visium)
• Strong understanding of genomics applications, including transcriptomics, epigenomics, and variant analysis
• Experience working in a core facility or shared resource environment with a strong service orientation
• Ability to develop, optimize, and validate wet‑lab protocols and implement new technologies
• Demonstrated ability to troubleshoot complex experimental issues and improve workflow efficiency
• Strong mentoring and training experience for junior staff in laboratory techniques and best practices
• Excellent communication skills with experience consulting with investigators on experimental design and sample requirements
• Experience supporting collaborative research projects and contributing to methods sections of manuscripts or grants

City of Hope is an equal opportunity employer.