Postdoctoral Fellow - Pancreatic Cancer

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission:
Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Beckman Research Institute of City of Hope is seeking a highly motivated Postdoctoral Fellow to join Dr. Jen Jen Yeh’s laboratory. The laboratory aims to understand the pathogenesis and pharmacogenomics of pancreatic cancer in order to accelerate treatment. Using a combination of molecular and genomic data and human-in-mouse models, the lab has identified four core subtypes in pancreatic cancer with important biologic and clinical implications.

• Focus on cancer genomics and personalized medicine, with responsibilities that include computational method development, data analysis, and experimental design.
• Integrate information from high-throughput screens, proteomic data, and next-generation sequencing data to generate and validate hypotheses of therapeutic relevance to pancreatic cancer.

• Ph.D. in Bioinformatics, Genetics, Genomics, or an equivalent field.
• Experience with common experimental techniques in molecular biology.
• Experience working with mouse models.
• Experience handling large datasets.
• Thorough understanding of common statistical tests and distributions.
• Ability to collaborate with experimental and computational team members.
• Comfort maintaining datasets, as well as displaying and interpreting processed data for publication.
• Demonstrated independence in developing new methods and troubleshooting.
• Ability to communicate scientific material and collaborate well with computational and non-computational partners.
• Excellent oral and written communication skills and the ability to perform both self-directed and guided research.
• Outstanding personal initiative and the ability to work effectively as part of a team.
• Willingness to assist in the mentorship and training of pre-doctoral researchers.
• Knowledge of rigor and reproducibility best practices.

• Thorough knowledge of cancer biology, epigenetics, proteomics, and transcriptomics.
• Familiarity with next-generation sequencing data analysis tools.
• Experience working in Linux environments, including batch job management on shared computing resources.
• Familiarity with a variety of supervised and unsupervised classification techniques.
• Proficiency in one or more statistical or scripting languages, preferably R or MATLAB.
• Knowledge of survival-based statistical analysis, such as Cox regression and Kaplan-Meier analysis.
• Working knowledge of machine learning best practices to avoid overfitting.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

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