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Director, Transformation Enterprise Program Office

Job in Durham, Durham County, North Carolina, 27709, USA
Listing for: Worldwide Clinical Trials
Full Time position
Listed on 2026-08-15
Job specializations:
  • Business
    Change Management
Job Description & How to Apply Below

Director, Transformation Enterprise Program Office

This is an opportunity to help a world-class specialty Contract Research Organization (CRO) bring its deep scientific expertise to new customers and new markets. The Director, Transformation Enterprise Program Office is a pivotal role within the Enterprise Program Management Office (EPMO). This position acts as the strategic partner and driving force for a dedicated portfolio of EPMO projects.

Each lead has a distinct area of deep expertise:

Change Management:
Focused on organizational readiness, stakeholder engagement, and adoption of new processes and tools.

Contract Research Organization (CRO) Operations:
Focused on enabling underlying process and technology improvements in a CRO context.

Technology Delivery:
Focused on guiding project teams to implement new technology across the enterprise.

Each Portfolio Lead will own and manage a portfolio of high-impact initiatives within their area of expertise, serving as the single point of contact for project teams. They will drive proactive planning, problem-solving, capability building, and progress tracking to ensure the successful execution and value realization of the portfolio.

While each role has a dedicated focus area, the Portfolio Leads will operate as a cohesive team, collaborating to align their portfolios, share insights, resolve cross-cutting issues, and contribute to the overall success of the EPMO. A Portfolio Lead may have direct reports. This team-based approach ensures that projects benefit from multidisciplinary expertise and a unified approach to execution.

The ideal candidate is a master facilitator, strategist, and coach with deep expertise in their domain (Change Management, CRO Operations, or Technology Implementation), a strong track record of navigating complexity, and the ability to support and enable project leaders to succeed.

What you will do:

  • Serve as the single point of contact for all projects within the assigned EPMO portfolio
  • Proactively engage with and support project teams to monitor progress and ensure the successful delivery of intended value and outcomes
  • Collaborate with Project Leaders to refine overall project plans, including the establishment of critical milestones and success metrics
  • Identify, analyze, and help resolve significant blockers to project success, such as lack of stakeholder alignment, fear of change, organizational capability gaps, etc.
  • Prepare and develop clear, concise documentation for executive- and board-level governance meetings
  • Lead comprehensive post-mortems to capture lessons learned and foster a culture of continuous improvement
  • Integrate the assigned portfolio of projects into the overall EPMO, ensuring alignment with broader enterprise objectives
  • Coach and mentor Project Leaders on best practices for executing successful, high-impact projects
  • Champion and guide the integration of Artificial Intelligence (AI) into project methodologies and solutions
  • Act as a key enabler of critical resources and support to Project Leaders, including access to expert interviews, targeted research, and analytical support
  • May supervise direct reports, supporting their performance and development
  • Perform other duties as assigned. The duties and responsibilities listed above are representative of the nature and level of work assigned and are not necessarily all-inclusive.

What you bring to the role:

  • Exceptional leadership and facilitation skills, with the ability to influence, motivate, and align cross-functional teams toward a common vision
  • Advanced strategic thinking, capable of synthesizing complex information and developing actionable plans that drive enterprise value
  • Outstanding communication abilities, both written and verbal, with a proven aptitude for preparing executive-level documentation and delivering high-impact presentations
  • Superior problem-solving and critical thinking skills, able to anticipate risks, analyze challenges from multiple perspectives, and implement effective solutions quickly
  • Strong organizational acumen, including the ability to manage multiple projects simultaneously and prioritize competing demands in a dynamic environment
  • Deep proficiency in project and portfolio management methodologies, Transformation Office techniques, tools, and best practices
  • High emotional intelligence and the ability to foster a culture of trust, engagement, and continuous improvement
  • Change management expertise, with a knack for guiding organizations through ambiguity and transformation
  • Flexible and adaptable, thriving in fast-paced, evolving environments, and embracing opportunities to innovate and learn
  • Technological curiosity and literacy, especially as it relates to emerging trends in Artificial Intelligence (AI) and digital transformation

Your experience:

  • Bachelor's degree in Finance, Economics, Accounting, Business Administration, Engineering, or a related field;
    Master's degree or certifications in Agile, Change Management, or Lean Six Sigma are a plus
  • Minimum of 5 years of Contract…
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