Site HSE Manager

Job Description Summary

The Manager, Health, Safety and Environment is responsible for supporting the expansion of Durham campus operations to include Large Molecule drug substance production at our new facility in RTP, NC. This essential position will develop, implement, and track the completion of HSE deliverables and needs—including design input, construction safety, and HSE operational readiness prior to the start of operations. The role will support overall project success and ensure robust implementation of HSE systems, programs, and controls before operations begin.

The Manager will be on the LMO SLT, acting as the primary point of contact for that platform and providing expert support across HSE topics.

Additionally, the role will serve as the functional lead for occupational safety programs across the Durham campus’s Gene Therapy/LMO/ADP operations. This position will lead the implementation of robust HSE programs to protect associates and the environment while contributing to a strong, proactive, and enabling HSE culture.

• Lead the design and implementation of robust HSE programs and controls to ensure safe and compliant start‑up of LMO production operations.

• Integrate LMO‑specific HSE requirements into site‑wide frameworks, including processes, systems, and training programs.

• Partner with internal teams and external providers to deliver world‑class safety performance, particularly across construction and operational activities.

• Serve as a trusted HSE advisor, providing expert guidance on risk management, regulatory compliance, and transparent reporting.

• Drive occupational safety excellence by leading critical programs such as process safety, electrical safety, fire protection, and emergency response.

• Collaborate cross‑functionally to embed HSE priorities into daily operations, aligning with broader site strategy and performance goals.

• Establish and monitor HSE metrics and KPIs, delivering actionable insights to support continuous improvement and leadership reporting.

• Build HSE capabilities across the site through training, engagement initiatives, and strong safety governance structures.

• Ensure comprehensive risk assessments, hazard analysis, and technical evaluations for new operations, equipment, and materials.

• Champion a high‑performance safety culture by leading audits, investigations, regulatory interactions, and continuous improvement initiatives.

• 8+ years of HSE program development/management experience in a manufacturing/laboratory environment, preferably within the biopharmaceutical industry.

• Prior experience supporting the design and start‑up of new LMO/ADP facilities and manufacturing operations (e.g., PHAs, P&n documentation review, HSE operational readiness) highly desired.

• Outstanding interpersonal skills for coaching and collaboration, with the ability to adapt communication styles based on audience and effectively advise on complex matters.

• Creative problem solver, strong multi‑tasker, and excellent oral and written communication skills.

• Bachelor’s or Master’s degree in Occupational Health & Safety, Environmental Science, Engineering, Biology, or a related field.

• Professional HSE certifications (e.g., CSP, CIH or equivalent) highly desired.

The salary for this position is expected to range between $ and $ annually. The final salary offered is determined based on relevant skills and experience and will be reviewed periodically. Candidates may also be eligible for performance‑based cash incentives and, depending on the level, annual equity awards.

US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and additional benefits. Employees are also eligible for a generous time‑off package, including vacation, personal days, holidays, and other leaves.

• Auditing
• Contractor Safety Management System
• Emergency Planning
• Environment Management
• Good Manufacturing Practices (GMP)
• Health Safety and Environment (HSE) Management Systems
• Incident Investigation…