Supervisor, Engineering Operations; Wed-Sat

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

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GRAIL is seeking a Supervisor, Engineering Operations to join the Engineering Operations organization. Engineering Operations is the engineering arm of Operations, providing hands‑on engineering, maintenance, and technical support to enable reliable, compliant, and scalable clinical laboratory operations. In this role, you will supervise and mentor a small team of engineers and technicians while serving as a technical leader supporting complex process automation hardware, laboratory equipment, and associated software systems.

You will work closely with Clinical Operations, Research Scientists, Quality, and Software Engineering to troubleshoot live production issues, restore operations quickly, and continuously improve system reliability and performance. As GRAIL’s testing volumes scale rapidly, this role is critical to ensuring operational continuity and regulatory compliance while helping deliver our revolutionary multi‑cancer early detection test to more patients.

You will work on‑site full‑time at our Durham, North Carolina (RTP) location.

This is a full‑time, first‑shift position working in the laboratory from 6:00 AM to 4:00 PM, Wednesday – Saturday
. Working hours may be temporarily adjusted due to training, travel, or business needs. This position includes on‑call responsibilities and may require weekend or holiday support.

• Supervise, coach, and support a small team of engineers and technicians performing live troubleshooting, recovery, debugging, repairs, and preventive maintenance of complex automation hardware and robotics, laboratory equipment and systems
• Provide day‑to‑day technical leadership to support clinical laboratory operations in compliance with cGMP/GLP and Quality Management System (QMS/eQMS) requirements
• Serve as a hands‑on technical lead with working knowledge of laboratory automation hardware, software, and process fundamentals
• Execute equipment lifecycle management activities, supporting installations, maintenance, calibration, qualification, repair, and decommissioning, ensuring complete and accurate documentation
• Maintain equipment records and traceability within asset management systems in compliance with CLIA/CAP, FDA 21 CFR Part 820, and ISO 13485 requirements
• Lead root cause investigations and failure analysis; drive corrective and preventive actions (CAPAs) for both hardware and software issues
• Make time‑sensitive technical decisions to restore operations and minimize downtime
• Drive continuous improvement initiatives to reduce unplanned maintenance and improve equipment reliability and maintainability
• Partner closely with Quality and Regulatory teams to ensure equipment lifecycle events meet applicable policies, procedures, and regulatory requirements
• Manage and coordinate external vendors supporting qualifications, calibrations, installations, upgrades, preventive maintenance, investigations, and repairs
• Respond to and resolve equipment‑related issues and environmental monitoring system alerts in a timely manner
• Lead and execute failure reporting, analysis, and corrective action systems
• Develop and deliver technical training; support creation of new training materials and transfer knowledge to engineers, technicians, and laboratory operators
• Pr…