Equipment Engineer

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi‑disciplinary organization of scientists, engineers, and physicians and we are using the power of next‑generation sequencing (NGS), population‑scale clinical studies, and state‑of‑the‑art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the Bay Area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit

The Equipment Engineer I will be responsible for supporting the development and documentation of return‑to‑service procedures following maintenance, repairs, or major modifications to advanced laboratory equipment, all in alignment with applicable regulatory requirements. The supported equipment spans a broad range, including next‑generation sequencing (NGS) platforms and automated liquid handling systems. The engineer will work closely with Engineering Operations, Process Engineering, Automation Engineering and Quality Assurance.

Success in this position requires strong interpersonal skills, effective technical writing, and exceptional troubleshooting abilities.

This position is onsite full‑time
, with 5 days per week at our Durham, NC facility. Additionally, the role requires participation in a rotating schedule for weekend and holiday coverage (when applicable), as part of ensuring continuous support for critical laboratory operations.

• Perform and document troubleshooting, recovery, debugging, and repairs on laboratory systems and equipment.
• Create and update: procedures, work instructions, guidelines, and testing documents such as installation / operational / verifications, standard operating procedures (SOP).
• Support root cause investigations that drive for resolutions to completion.
• Execute Equipment Lifecycle Management processes and procedures by supporting and maintaining equipment records for traceability purposes in compliance with CLIA/CAP and ISO 13485 requirements.
• Collaborate with validation engineers to draft, review and execute equipment qualification protocols.
• Recommend and implement changes to ensure ongoing high‑quality and efficient engineering operations procedures as part of the continuous improvement process.
• Support the planning and execution of qualification activities ensuring compliance with established procedures and guidelines.
• Participate and adhere to GRAIL’s policies and guidelines.
• Work closely with Compliance, Engineering, Quality and Regulatory to implement and follow the required policies and procedures for the lifecycle of equipments.
• Partner cross‑functionally to enable effective technology transfer and continuous workflow improvements.

• Bachelor’s degree or equivalent in Engineering, Physics, Chemistry, or similar Life Sciences discipline.
• 1+ years generating technical documentation within a regulated environment.
• 1+ years experience completing work in accordance with stated deadlines.
• 1+ years experience contributing to cross‑functional team initiatives.
• 1+ years technical troubleshooting and root cause analysis experience.
• Good to excellent communication skills to work independently and provide internal customer support.
• Good to excellent time management skills to support a fast‑paced working environment.
• Basic to good knowledge of laboratory equipment and systems.
• Basic to good knowledge creating and interpreting process and material flow diagrams.
• Ability to take initiative and independently drive projects to completion with detailed and efficient execution and reporting.

• Bachelor’s degree or equivalent in Engineering preferred.
• 1+ years experience with asset management softwares.
• 1+ years experience using Laboratory Information…