Equipment Engineer Night Shift Wed - Sat

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit

The Equipment Engineer 2 provides professional engineering support in the evaluation, installation, optimization, and maintenance of manufacturing equipment and automation systems. Operating with increasing independence, this role applies engineering principles to analyze equipment performance, resolve technical issues, and contribute to improvements that enhance reliability, efficiency, and compliance. The position partners with cross‑functional teams to implement engineering solutions, maintain accurate technical documentation, and ensure equipment systems operate effectively within defined standards and operational goals.

You will work on‑site full‑time at our office located in Durham, NC

• Conduct professional engineering analyses to assess equipment performance, identify reliability concerns, and develop data‑driven recommendations for improvement.
• Support the installation, modification, and qualification of laboratory manufacturing equipment by applying engineering principles and collaborating with technicians, engineers, and operations teams.
• Execute advanced maintenance, repair, and technical adjustments on complex manufacturing equipment by applying extensive procedural knowledge and hands‑on expertise.
• Apply structured problem‑solving methods to troubleshoot equipment issues, develop corrective actions, and implement improvements that strengthen equipment reliability.
• Develop, update, and maintain engineering documentation, including technical specifications, process instructions, test results, and change records, in accordance with engineering controls.
• Collaborate with cross‑functional partners on continuous improvement initiatives, contributing engineering insights that enhance equipment capability, throughput, and performance.
• Support preventive and predictive maintenance programs by evaluating equipment behavior, reviewing failure data, and recommending engineering‑driven reliability enhancements.
• Perform engineering‑level testing, calibration, and verification activities to ensure equipment accuracy and compliance with quality and safety standards.
• Exercise professional judgment within established engineering practices to ensure safe, compliant, and efficient operation of manufacturing equipment.
• These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion.

• Bachelor’s degree in mechanical engineering, electrical engineering, manufacturing engineering, or related discipline.
• 2+ years of relevant experience in equipment engineering, manufacturing, or maintenance engineering, or a master’s degree with 0–2 years of experience.
• Demonstrated knowledge of automated manufacturing systems, control systems, and process instrumentation.
• Proficiency in reading and interpreting mechanical and electrical drawings and schematics.
• Familiarity with root cause analysis and failure mode and effects analysis (FMEA) tools.
• Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position’s complexity and scope, contributing to organizational regulatory compliance. Minimal applicable standards for this position include:
  • GMP quality management systems (e.g., ISO 13485)
  • Clinical…