Bioinformatics Scientist

Bioinformatics Scientist

Guidehouse seeks a Bioinformatics Scientist to advance our research programs with a primary focus on single‑cell and spatial omics data analysis. This is a full‑time, on‑site position in Durham, NC. Travel:
None.

Clearance Required:

Ability to Obtain Public Trust.

• Provide bioinformatics support for single‑cell and spatial omics and other sequencing data.
• Collaborate with scientists to design, analyze, manage and interpret all types of data.
• Conduct analyses on Next‑Gen sequencing data (ChIP‑Seq, RNA‑Seq, miRNA‑Seq, etc.) and other experimental models.
• Work with interdisciplinary teams to apply computational data analysis approaches for biological discoveries.
• Perform advanced statistical and computational analyses to interpret complex datasets and derive actionable insights.
• Integrate and analyze diverse genomic and multi‑omic datasets, including sequencing and public data sources.
• Develop, optimize, and maintain bioinformatics pipelines, scripts, and computational tools for large‑scale data analysis (NGS, scRNA‑seq, multi‑omics).
• Install, configure, and support scientific software across computing platforms, ensuring reproducibility through standardized workflows and documentation.
• Generate reports, visualizations, and presentations to communicate findings to scientific and technical audiences.
• Evaluate and implement new bioinformatics tools, statistical methods, and computational approaches based on current literature and research needs.
• Provide training and technical guidance to staff on bioinformatics tools, pipelines, and data analysis techniques.
• Maintain detailed documentation, laboratory records, and progress reports; present findings at meetings and contribute to publications.

• Master’s degree in bioinformatics, biostatistics, computational biology or a related biological/life science field.
• At least 2 years of data analysis experience.
• Advanced proficiency in statistical modeling, machine learning, and integrative analysis.
• Knowledgeable with a variety of next‑gen sequencing techniques.
• Experience with analytical tools, software and platforms such as R, Python, MATLAB, SAS, PERL, Java, Shell, Bash, Seurat, Scanpy, Linux, Unix, Bioconductor, cloud computing, and high‑performance computing.
• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates with an active public trust or suitability are preferred.

• PhD preferred.
• Strong verbal and written communication skills.
• Experience collaborating closely with investigators and multidisciplinary teams to design analytical strategies, ensure data quality, interpret results, and translate findings into actionable scientific conclusions.

• Competitive compensation and a flexible benefits package.
• Medical, Rx, dental and vision insurance.
• Personal and family sick time with company‑paid holidays.
• Parental leave.
• 401(k) retirement plan.
• Group term life and travel assistance.
• Voluntary life and AD&D insurance.
• Health savings account, health care and dependent care flexible spending accounts.
• Transit and parking commuter benefits.
• Short‑term and long‑term disability.
• Tuition reimbursement, personal development, certifications and learning opportunities.
• Employee referral program and corporate‑sponsored events.
• Community outreach and  membership.
• Supplemental benefits via Corestream (critical care, hospital indemnity, accident insurance, legal assistance and  protection).
• Position may be eligible for a discretionary variable incentive bonus.

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation. Guidehouse will consider qualified applicants with criminal histories in a manner consistent with applicable law or ordinance, including the Fair Chance Ordinance of Los Angeles and San Francisco.