Clinical Research Nurse - Wilmington, NC

Job Title: Clinical Research Nurse - Wilmington, NC

We’re hiring a Clinical Research RN to support innovative clinical trials with one of the leading healthcare providers in the U.S. The role is based in Wilmington, NC—a beautiful coastal city just a couple hours from Raleigh, offering a much more relaxed, beach-centered lifestyle.

We are seeking a Clinical Research Nurse (CRN) to perform technical and clinical requirements for study protocols. This includes tasks such as venipuncture, specimen processing, vital signs monitoring, electrocardiograms, IV infusions, and other procedures necessary for study protocols.

• Perform technical and clinical requirements of study protocols, such as venipuncture and specimen processing.
• Attend investigator meetings, site initiation visits, and coordinator meetings for training on drug preparation and administration.
• Monitor for complications with study drug administration, focusing on injections and intravenous infusions.
• Maintain accurate dispensing logs, including information about lot numbers and drug vs. placebo.
• Document laboratory data and adverse reactions, notifying investigators and sponsors of serious events.
• Assist other staff as needed and participate actively in patient recruitment for clinical trials.
• Complete training on the Clinical Trial Management System, updating databases and handling participant reimbursements.
• Communicate patient recruitment status and clinical needs to investigators and site managers.
• Maintain relationships with monitors from sponsoring companies through various forms of communication.
• Promote the site for future trials and respond to queries promptly.
• Prepare study documentation for audits and assist auditors during the audit process.
• Order clinical supplies, monitor protocol-specific rescue drugs, and manage code/crash cart assessments.
• Monitor and maintain temperature controls for investigational product storage.
• Maintain certification for packaging and shipping specimens on dry ice.
• Act as the OSHA Representative for the site, maintaining employee immunization records and administering vaccines.
• Perform equipment calibration as needed and support training and development of clinical skills for site staff.
• Travel to other sites within the network may be required to support workload increases or studies/projects.

• Active RN license for NC.
• 1+ years of prior CRC/CRN/Research experience is ideal.
• If no prior research experience, a minimum of 2+ years of bedside nursing experience is required.
• IV Insertion experience is a significant advantage.

• Chart review
• Patient recruitment
• EDC and EMR proficiency
• Clinical research
• GCP knowledge
• Pre-screening patients
• Phlebotomy skills

The role is based on-site for 5 days a week (Monday to Friday), totaling 40 hours. Opportunities for advancement include progression from CRC I to CRC II, CRN, Team Lead, Project Manager, and more.

This is a Contract to Hire position based out of Durham, NC.

Pay range: $40.00 – $50.00 per hour.

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre‑tax and Roth post‑tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long‑term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Fully onsite in Durham, NC.

This position is anticipated to close on Jun 15, 2026.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

San Francisco Fair Chance Ordinance:
For all positions located in the city and county of San Francisco, we will consider qualified applicants with arrest and conviction records.

Massachusetts Lie Detector:
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment.

Use of Artificial Intelligence (AI):
We may use AI to support parts of our hiring process. Final decisions are made by our hiring team. By applying, you acknowledge that your application may be reviewed using AI tools.

If you would like to request a reasonable accommodation, please email actalentaccom