Postdoctoral Associate

Postdoctoral Associate in Structural Biology & Biophysics Lee Lab | Duke University School of Medicine

A NIH-funded postdoctoral research position is available in the laboratory of Dr. Seok-Yong Lee at the Duke University School of Medicine. We are seeking a highly motivated and independent scientist to investigate the molecular mechanisms of membrane transport proteins and ion channels essential to human health. The successful candidate will lead projects focused on cryo-EM structure determination and the biochemical/biophysical characterization of complex membrane transport systems.

Minimum Requirements:

• Education:
  
  Ph.D. in Biochemistry, Biophysics, Chemistry, or a closely related field.
• Technical Expertise:
  Experience in membrane protein biochemistry and cryo-EM.
• Biophysical
  
  Skills:
  
  Proficiency in biophysical techniques such as CD, ITC, NMR, EPR, or fluorescence spectroscopy and quantitative analysis.
• Attributes: A strong publication record, excellent communication skills, and a desire to master new technologies in a highly collaborative setting.

Key Responsibilities:

• Structural Studies:
  Executing the full cryo-EM workflow, including sample preparation/freezing, data collection, processing, and atomic model building.
• Biochemical/Biophysical Characterization:
  Managing protein engineering (cloning, expression, and purification) and conducting functional assays to validate structural findings.
• Cellular & In Vivo Integration:
  Utilizing light microscopy for in situ protein characterization and performing necessary animal handling for physiological relevance.
• Collaboration:
  
  Working within a multidisciplinary team to integrate structural data with electrophysiology and computational modeling.

Research Environment Candidates will join a vibrant, well-funded research group with a track record of high-impact publications. The lab provides access to state-of-the-art facilities at Duke, including world-class cryo-EM suites and advanced imaging instrumentation.

Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status. Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes.

To achieve this exchange, it is essential that all members of our community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values. Essential Physical

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