Sr. Research Associate, Delivery

## Sr. Research Associate, Delivery Apply remote type:
Onsite locations:
Durham, NCtime type:
Full time posted on:
Posted 2 Days Agojob requisition :
R26-91

Ask Bio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease.

Ask Bio’s gene therapy platform includes Pro
10TM, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.
** Our vision:
** Pioneering science to create transformative molecular medicines.
** Our mission:
** Lead innovative science and drive clinical outcomes to transform people's lives.
** Our principles:
*** Advance innovative science by pushing boundaries.
* Bring transformative therapeutics to patients in need.
* Provide an environment for employees to reach their fullest potential.
** Our values:
*** Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
* Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
* Embrace Responsibility. We are humbled by the enormity of our mission.  We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
* Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
* Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.
** Position Summary
** Ask Bio is seeking a highly motivated, enthusiastic, and collaborative Senior Research Associate to support the development and discovery of next-generation gene therapies utilizing state-of-the-art non-viral delivery technologies. The Senior Research Associate will work directly with the non-viral delivery team to conduct experiments that advance our preclinical therapeutic pipeline.

The ideal candidate will have hands-on experience with standard molecular biology techniques, including: (1) isolation of DNA, RNA, and protein from cells and tissues; and (2) quantitative PCR (qPCR), RT-PCR, ddPCR, ELISA, SDS-PAGE, and Western blot. Prior experience with research-grade lipid nanoparticle (LNP) formulation is preferred.

This position is based in Morrisville, North Carolina.
** Job Responsibilities
*** Perform plasmid purification, genomic DNA extraction, RNA extraction, and PCR-based assays (PCR, qPCR, ddPCR)
* Conduct small-scale LNP formulation and analytical characterization for early research and preclinical in vivo and in vitro studies
* Perform in vitro cell-based assays, including plasmid transfection, AAV transduction, LNP transfection, and primary cell culture
* Analyze data and effectively communicate results through formal reports and presentations for internal and external stakeholders
* Develop detailed experimental protocols and maintain an electronic laboratory notebook in accordance with good documentation and data integrity practices
* Maintain inventory and order reagents and materials to support timely project execution
* Ensure laboratory areas are clean, organized, and adequately stocked with necessary equipment and supplies
** Minimum Requirements
*** Bachelor’s degree in molecular biology, Biochemistry, or a related field with 5+ years of research experience; OR a Master’s degree in molecular biology, Biochemistry, or a related field with 2+ years…