Sr. Scientist, Molecular Biodistribution

Opportunity for Secondment to Ask Bio

We're pleased to share an exciting secondment opportunity at Ask Bio.

This role is available for a time period to be determined by leadership at both Bayer and Ask Bio. While most assignments range from one to two years, the exact duration will be based on business needs and mutual agreement.

This secondment offers a unique chance to broaden your experience, expand your knowledge, and contribute meaningfully to Ask Bio's mission: to advance gene therapy and change the lives of patients around the world.

If you're interested in exploring this opportunity, we encourage you to:

• Speak with your direct manager to discuss your interest and alignment with your development goals.
• Apply directly using the link provided in the posting.

We look forward to seeing how our colleagues continue to grow and make an impact across the Bayer-Ask Bio partnership.

Our vision:
Pioneering science to create transformative molecular medicines.

Our mission:
Lead innovative science and drive clinical outcomes to transform people's lives.

Our principles:

• Advance innovative science by pushing boundaries.
• Bring transformative therapeutics to patients in need.
• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
• Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.

Position Summary

The Senior Scientist, Molecular Biodistribution leads and executes biodistribution and gene expression assessment strategies. This role is responsible for designing fit-for-purpose molecular assays, generating high-quality tissue distribution and transgene expression data, and interpreting results to inform candidate selection, dose strategy, safety assessment, and support regulatory submissions.

The role partners closely with Product Development, Translation Medicine, Tech Ops, and Research and Development among other functions. The successful candidate combines deep hands-on technical expertise with strong scientific judgment in assay development, data analysis and interpretation, and cross-functional communication.

This is an onsite position in RTP, NC and will report to the Director, Product Development Cores.

Job Responsibilities

Biodistribution Strategy and Study Support

• Design and support biodistribution and gene expression assessment plans for genetic medicine programs
• Define fit-for-purpose tissue collection, processing, and analytical strategies for biodistribution, persistence, and transgene expression assessments
• Contribute to dose selection, route-of-administration evaluation, and tissue targeting assessments for AAV and other genetic medicine platforms
• Evaluate data in the context of mechanism of action, tissue tropism, vector performance, and nonclinical efficacy

Assay Development and Execution

• Develop, optimize, and troubleshoot molecular assays to quantify vector genomes, transgene expression, and related biomarkers in tissues and biofluids
• Apply and oversee quantitative PCR-based and related molecular methods, including qPCR, ddPCR, RT-qPCR, and other nucleic acid quantification approaches
• Establish assay controls, standards, acceptance criteria, normalization strategies, and data quality practices appropriate for regulated and non-regulated studies
• Collaborate with internal stakeholders external partners to ensure reliable assay execution, method transfer, and sample analysis
• Drive continuous improvement in assay sensitivity, specificity, reproducibility, and operational scalability

Data Analysis and Interpretation

• Analyze and interpret biodistribution and gene expression datasets to support program decisions in research and development
• Assess vector genome copy number, transgene RNA expression, and relationships across dose, tissue, timepoint, and platform
• Identify technical or biological sources of variability and recommend follow-up experiments or analytical refinements
• Summarize findings in clear scientific narratives for study reports, governance discussions, and regulatory documentation
• Present results and recommendations to cross-functional teams and senior stakeholders in genetic medicine

Minimum Requirements

• PhD in molecular biology, pharmacology, bioanalytical sciences, genetics, biomedical sciences, or a related discipline with 5+ years' relevant work experience; or Master's degree in molecular biology, pharmacology, bioanalytical…