Senior Research Associate, Biodistribution

Ask Bio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease.

Ask Bio’s gene therapy platform includes Pro
10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.

Pioneering science to create transformative molecular medicines.

Lead innovative science and drive clinical outcomes to transform people's lives.

• Advance innovative science by pushing boundaries.
• Bring transformative therapeutics to patients in need.
• Provide an environment for employees to reach their fullest potential.

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
• Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

The Senior
Research Associate, Molecular Biodistribution executes biodistribution and gene expression assessment experiments. This role is responsible for executing fit-for-purpose molecular assays, generating high-quality tissue distribution and transgene expression data, and interpreting results to inform candidate selection, dose strategy, safety assessment, and support regulatory submissions.

The role partners closely with Product Development, Translation Medicine, Tech Ops, and Research and Development among other functions. The successful candidate combines hands‑on technical experience with scientific judgment in assay development, data analysis and interpretation, and cross‑functional communication.

This position will be onsite in RTP, NC and will report to the Director, Product Development Cores.

Assay Development and Execution

• Develop, optimize, and troubleshoot molecular assays to quantify vector genomes, transgene expression, and related biomarkers in tissues and biofluids.
• Apply and oversee quantitative PCR-based and related molecular methods, including qPCR, ddPCR, RT-qPCR, and other nucleic acid quantification approaches.
• Establish assay controls, standards, acceptance criteria, normalization strategies, and data quality practices appropriate for regulated and non-regulated studies.
• Collaborate with internal stakeholders external partners to ensure reliable assay execution, method transfer, and sample analysis.
• Drive continuous improvement in assay sensitivity, specificity, reproducibility, and operational scalability.

Data Analysis and Interpretation

• Analyze and interpret biodistribution and gene expression datasets to support program decisions in research and development.
• Assess vector genome copy number, transgene RNA expression, and relationships across dose, tissue, timepoint, and platform.
• Identify technical or biological sources of variability and recommend follow-up experiments or analytical refinements.
• Summarize findings in clear scientific narratives for study reports, governance discussions, and regulatory…