Senior Manager, Research Laboratory Operations

Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments.

Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit  for more information.

We are seeking a highly organized, collaborative, and motivated Senior Manager, Research Laboratory Operations to lead our research laboratory in Durham, NC, and actively participate as a hands‑on scientific partner on key research projects. Reporting directly to the Chief Scientific Officer (CSO), Oncology, this dual-function role is pivotal in ensuring the smooth, safe, and compliant daily operation of our research facility while directly contributing scientific expertise to advance our pipeline.

The ideal candidate will seamlessly blend strong laboratory operations leadership with a solid background in drug discovery, specifically offering hands‑on experience in screening methodologies, biochemical assays, and cell culture.

• Research Laboratory Operations & Management (approx. 60%)
• Laboratory Management:
  Oversee the daily operations of the Durham research lab, maintaining an efficient, highly organized, safe, and fully functional environment for the scientific team.
• Equipment & Inventory:
  Manage the procurement, maintenance, decontamination, calibration, and repair of all laboratory equipment (including biosafety cabinets, live cell imaging systems, liquid handlers, and other analytical instruments). Oversee inventory and supply chain for lab consumables, reagents, and specialized materials.
• Safety & Compliance:
  Ensure all laboratory activities comply with institutional, local, state, and federal safety regulations (including OSHA and biosafety guidelines). Oversee lab safety protocols, hazardous waste disposal, and general laboratory hygiene.
• Budget & Vendor Management:
  Manage laboratory spending, assist in tracking the operational budget, process purchase approvals, and coordinate with external vendors, contractors, and service providers.
• Cross‑Functional
  
  Collaboration:
  
  Partner with facilities management, EH&S, procurement, and R&D project management to coordinate space planning, equipment utilization, and continuous operational improvements.
• Scientific Project Contribution (approx. 40%)
• Assay Development & Execution:
  Support ongoing pipeline programs by conducting hands‑on in vitro research, with a strong focus on screening platforms and biochemical assays.
• Experimental Support:
  Manage cell cultures of cancer and normal cell lines; execute mechanism of action, target validation, and biomarker studies for therapeutic candidates.
• Data & Documentation:
  Document and archive experimental protocols, raw data, analyses, and conclusions according to established laboratory procedures and electronic lab notebook (ELN) standards.
• Scientific Communication:
  Actively participate in the communication of research findings, presenting data in internal project team meetings, contributing to conference abstracts, and supporting the preparation of manuscripts for publication.

• Education:
  
  MS or…