Executive Director, Global Program Leader

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & amp;
Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking an Executive Director, Global Program Leader as part of the Research & Development team based in Somerset, NJ
.

The Executive Director, Global Program Leader (GPL) is a senior strategic leadership role responsible for the overall development, execution, and governance of Legend Biotech's in vivo CAR-T programs.

Reporting directly to the President of R&D, the GPL serves as the single point of accountability for leading cross-functional teams to define and execute integrated global development strategies from IND enabling through clinical proof-of-concept, late-stage development, registration, and lifecycle management. The GPL ensures alignment of program strategy, timelines, resources, and operational execution across Research, Clinical Development, Regulatory Affairs, Translational Sciences, Technical Development, Manufacturing, Commercial, Business Development, and other key functions.

The successful candidate will combine strong scientific and clinical development expertise with exceptional leadership, strategic thinking, and execution capabilities to advance innovative in vivo CAR-T therapies for patients worldwide.

• Partner closely with Clinical Development and Regulatory Affairs to design efficient development pathways that maximize speed to proof-of-concept, pivotal development, and global approvals.

• Guide critical regulatory interactions and major health authority milestones.

• Ensure readiness and alignment for INDs, CTAs, BLA/MAA submissions, and lifecycle management activities.

• Chair Global Program Teams and provide leadership across all functional areas involved in program execution.

• Foster effective collaboration among Research, Translational Medicine, Clinical Development, Regulatory Affairs, Biometrics, CMC, Quality, Manufacturing, Commercial, Finance, and Business Development.

• Drive cross-functional problem-solving and ensure timely resolution of strategic and operational risks.

• Establish clear governance processes, decision frameworks, and accountability mechanisms.

• Present program strategies, risks, and recommendations to executive leadership and governance committees.

• Lead preparation of development scenarios, investment analyses, milestone recommendations, and portfolio reviews.

• Provide regular updates to senior management on program status, emerging opportunities, and critical risks.

• Ensure effective risk management and contingency planning throughout development.

• Represent Legend Biotech in interactions with external partners, collaborators, investigators, key opinion leaders, and other stakeholders.

• Support business development assessments, diligence activities, and partnership opportunities related to in vivo CAR-T technologies.

• Serve as a scientific and strategic ambassador for Legend’s in vivo CAR-T platform.

• Build a high-performance, patient-focused, and collaborative program culture.

• Mentor and develop program management and cross-functional team members.

• Champion innovation, accountability, and operational excellence across development teams.

• MD, PhD, PharmD, or equivalent advanced scientific or medical degree required.

• Advanced training in oncology, immunology, cell and…