Scientist, Medical Technologist & Lab Technician, Clinical Research

Job Description

Job Description

This role focuses on performing advanced cell culture and genetic toxicology studies to support research aimed at developing cancer therapies. The scientist will work hands-on with suspension cell lines, and preferably adherent cell lines, to maintain healthy cultures, perform in vitro micronucleus (IVMN) assays, and support in vivo dosing studies in an animal research environment. The position requires strong aseptic technique, meticulous laboratory documentation, and the ability to work effectively in a fast-paced, regulated laboratory setting.

• Maintain and expand suspension cell cultures, ensuring healthy growth and stable cell populations under aseptic conditions.
• Monitor and document cell morphology, viability, growth characteristics, and cell density to evaluate overall culture health and performance.
• Identify, troubleshoot, and respond appropriately to culture abnormalities or changes in cell behavior.
• Perform cell treatments and exposures under a variety of conditions, including short- and long-term exposure periods, varying incubation temperatures, environmental conditions, cell densities, and recovery intervals.
• Conduct cell harvesting procedures and sample preparation techniques to support downstream analyses.
• Prepare microscope slides and analyze cellular samples, preferably using fluorescence microscopy, for genetic toxicology assessments such as micronucleus identification and scoring.
• Perform and document standard cell culture calculations, including Population Doubling (PD), Relative Population Doubling (RPD), and Relative Increase in Cell Count (RICC), and ensure accuracy of all recorded data.
• Accurately record, interpret, and report experimental results in a regulated laboratory environment, following established procedures and Good Laboratory Practices (GLP).
• Recognize and differentiate common cell culture contaminants, including bacterial, yeast, fungal, mycoplasma, and other microbial contaminants, and take appropriate preventive and corrective actions.
• Receive, evaluate, and process test articles submitted for testing, ensuring proper handling, storage, and documentation.
• Communicate and coordinate sample preparation and scheduling with scientific staff and Study Directors to align with study protocols and timelines.
• Determine surface area and calculate required extraction ratios for test articles, and prepare samples and dosing solutions according to standard operating procedures and study protocols using aseptic technique.
• Meticulously maintain precise records of all sample preparations, extractions, and dosing solutions in accordance with Good Laboratory Practices.
• Maintain a clean, organized, and compliant work area, adhering to laboratory safety and quality standards.
• Follow all laboratory safety requirements and wear a respirator safely when needed as part of routine or specific procedures.
• Run in vitro assays, including IVMN assays when applicable, following internal laboratory procedures and established historical image sets for micronucleus identification and scoring.
• Review study protocols regularly to determine daily and weekly activities, ensuring that all scheduled assays and tasks are completed on time.
• Participate in dosing studies in the vivarium, including weighing animals, administering test articles (such as single injections), and observing animals as required by study protocols.
• Assist with animal handling activities such as wrapping animals when needed to safely perform dosing and observation procedures.
• Prepare and contribute to study reports and documentation for both in vitro and in vivo testing, ensuring clarity, accuracy, and regulatory compliance.
• Support medical device testing by preparing devices for testing, performing extractions, disassembly, and preparation for ISO-related testing as needed.
• Lead and mentor less experienced personnel in hands-on laboratory tasks, reinforcing best practices in aseptic technique, documentation, and safety.
• Adapt to a fast-paced environment where schedules may change based on client needs, while maintaining high-quality work and clear communication with the team.

• Hands-on cell culture experience with suspension cell lines in a laboratory environment.
• Demonstrated proficiency in aseptic technique for all cell culture and sample preparation activities.
• Experience maintaining healthy cell cultures, including monitoring cell morphology, viability, growth characteristics, and cell density.
• Ability to evaluate overall cell population health and culture performance and respond a