Senior In Vitro Scientist
Job in
Emeryville, Alameda County, California, 94608, USA
Listed on 2026-08-31
Listing for:
The Fountain Group LLC
Full Time
position Listed on 2026-08-31
Job specializations:
-
Research/Development
Pharmaceutical Science/ Research, Research Scientist, Drug Discovery
Job Description & How to Apply Below
Duration:18 months
Location:
Onsite – Emeryville, CA
About the Role
- We are seeking a highly motivated and collaborative Senior Scientist to support the development and execution of in vitro ADME assays for the evaluation and optimization of potential therapeutic candidates. This onsite role, based in Emeryville, CA, will contribute to drug discovery programs by generating high quality data to inform compound progression and candidate selection.
- The ideal candidate will have hands-on experience conducting in vitro ADME assays in a biopharmaceutical, pharmaceutical, or contract research organization setting, with strong technical expertise in LCMS/MS, enzyme kinetics, cell-based assays, and data interpretation.
- Design, develop, and execute in vitro ADME assays to support drug discovery and candidate optimization.
- Conduct ADME screening studies, including but not limited to microsomal stability, hepatocyte stability, permeability, plasma protein binding, and related metabolism assays.
- Generate, analyze, interpret, and report high quality data to support project decisions and compound progression.
- Collaborate closely with DMPK, biology, chemistry, and project team members to ensure timely delivery of decision enabling data.
- Design and troubleshoot in vitro experiments to address project specific questions related to compound metabolism, stability, permeability, and protein binding.
- Contribute to LCMS/MS bioanalytical method development, sample analysis, assay optimization, and troubleshooting.
- Apply enzyme kinetic and quantitative bioanalytical principles to support assay design and data interpretation.
- Prepare experimental protocols, study summaries, technical reports, and presentations for internal stakeholders and project teams.
- Maintain accurate documentation in electronic laboratory notebooks and ensure adherence to internal quality and safety standards.
- Support implementation and use of laboratory automation platforms, as applicable.
- BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
- Minimum of 2 years of relevant hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
- Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
- Demonstrated experience designing and executing automated in vitro assays to evaluate and optimize ADME properties of drug candidates.
- Handson experience with LCMS/MS based sample analysis; experience with Sciex instruments is preferred.
- Proficiency with data analysis and visualization tools such as Microsoft Excel, Graph Pad Prism, Analyst, or similar software.
- Experience using electronic laboratory notebooks.
- Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.
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Position Requirements
10+ Years
work experience
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