Senior Scientist

Duration: 18 Months (High Possibility of Extension) Responsibilities

• Design, develop, and execute in vitro ADME assays to support drug discovery and candidate optimization.
• Conduct ADME screening studies, including but not limited to microsomal stability, hepatocyte stability, permeability, plasma protein binding, and related metabolism assays.
• Generate, analyze, interpret, and report high-quality data to support project decisions and compound progression.
• Design and troubleshoot in vitro experiments to address project-specific questions related to compound metabolism, stability, permeability, and protein binding.
• Contribute to LC-MS/MS bioanalytical method development, sample analysis, assay optimization, and troubleshooting.
• Apply enzyme kinetic and quantitative bioanalytical principles to support assay design and data interpretation.
• Maintain accurate documentation in electronic laboratory notebooks and ensure adherence to internal quality and safety standards.
• Support implementation and use of laboratory automation platforms, as applicable.

• BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
• Minimum of 2 years of relevant hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
• Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
• Demonstrated experience designing and executing automated in vitro assays to evaluate and optimize ADME properties of drug candidates.
• Hands-on experience with LC-MS/MS-based sample analysis; experience with Sciex instruments is preferred.
• Proficiency with data analysis and visualization tools such as Microsoft Excel, Graph Pad Prism, Analyst, or similar software.
• Experience using electronic laboratory notebooks.
• Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.