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Associate Principal Scientist, Regenerative Immunology
Job in
Englewood, Bergen County, New Jersey, 07631, USA
Listed on 2026-06-26
Listing for:
InVitro Cell Research, LLC
Full Time
position Listed on 2026-06-26
Job specializations:
-
Research/Development
Research Scientist, Immunology Research, Medical Science
Job Description & How to Apply Below
ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs.
With ICR, you'll get to:- Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
- Contribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideas
- Design and optimize directed-differentiation protocols to generate functional, TECs from human iPSCs
- Build, characterize and validate 3D thymic organoids capable of supporting de novo T-cell development
- Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm
- A PhD or MD/PhD
- At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology
- Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineering
- Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitution
- Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell culture
- Experience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitution
- Even if you don't meet all of these criteria, please apply anyway
- An easygoing, friendly personality
- The ability to work in the United States without sponsorship
If you don't combine your cover letter with your CV or resume when you apply through Linked In, after you apply please send your cover letter only to: with "Cover [Your name]" as the Subject line.
Position title and compensation are commensurate with experience.
The compensation ranges listed below are starting ranges. Starting base pay range: $160,000/yr - $215,000/yr#J-18808-LjbffrPosition Requirements
10+ Years
work experience
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