Precision Oncology SME

Position Summary

Prometheus Federal Services (PFS) is a trusted partner of federal health agencies. We are exploring adding a highly experienced

Precision Oncology Subject Matter Expert(SME) to support a nationally significant federal precision medicine initiative focused on molecular testing, precision oncology, and evidence-based cancer care. In this role, the candidate will provide strategic clinical and scientificexpertiseto inform program direction, molecular testing guidance, implementation strategies, and stakeholder engagement activities. The ideal candidate willpossessdeepexpertisein oncology, precision medicine, molecular diagnostics, and cancer genetics, with the ability to translate complex scientific evidence into practical clinical and operational recommendations.

This individual will collaborate with multidisciplinary teams, healthcare leaders, and federal stakeholders to advance standardized approaches to molecular testing and precision oncology across diverse healthcare environments.

• Provide subject matterexpertisein oncology, precision medicine, molecular diagnostics,andcancer genetics
• Support precision oncology programs by translating emerging scientific evidence into actionable clinical or programmatic guidance.
• Apply and interpretNCCN Clinical Practice Guidelines and other evidence-based oncology care pathways to support clinical decision‑making.
• Review, interpret, and advise on molecular testing strategies, biomarkers, assay platforms, and specimenselectionacross the cancer care continuum.
• Develop,maintain, orprovideexpert guidance on molecular testing recommendations across various cancer types and clinical scenarios.
• Provide specializedexpertisein hematologic malignancies, including molecular testing approaches and biomarker interpretation.
• Collaborate with clinical, operational, and leadership stakeholders to support precision oncology initiatives and program objectives.
• Communicate complex scientific and clinical concepts effectively to diverse audiences, including clinicians, administrators, and executive leadership.
• Support enterprise-wide efforts to standardize molecular testing practices and precision oncology workflows.

• MD or PhD in Oncology, Hematology/Oncology, Molecular Pathology, Genetics, Immunology, or a closely related field.
• Demonstratedexpertisein oncology, precision medicine, molecular diagnostics, and cancer genetics.
• Strong knowledge of NCCN Clinical Practice Guidelines and evidence-based oncology care pathways.
• Experience supporting precision oncology programs and translating scientific evidence into clinical practice, policy, or program guidance.
• Expertise in hematologic malignancies and molecular testing applications for hematologic cancers.
• Knowledge of molecular assay platforms, biomarker testing, specimen requirements, and testing methodologies across the cancer care continuum.
• Experience developing, evaluating, or advising onmolecular testing guidance and clinical recommendations.
• Excellent written, verbal, and presentation skills with the ability to communicate complex scientific concepts to technical and non-technical audiences.
• Ability to work in the U.S. indefinitely without sponsorship
• Ability to obtain a public trust

• Direct experience supporting VA, VHA, NPOP, or other national precision oncology programs.
• Experience supporting national molecular testing programs, multi-vendor testing models, or enterprise-level standardization initiatives.
• Familiarity with implementing molecular testing guidance across academic, community, federal, or integrated healthcare delivery settings.
• Experience working with multidisciplinary oncology teams, laboratory leaders, and healthcare executives to advance precision medicine programs.

PFS offers a benefits package that may include health, dental, and vision coverage; flexible spending accounts; disability and life insurance; a retirement plan; paid time off; and other programs to support employees and their families. Learn more about PFS Benefits.

• health, dental, and vision coverage
• flexible spending accounts
• disability and life insurance
• a retirement plan
• paid time off
• other programs to support employees and their families

Salary Range: $170,000 - $200,000

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, parental status, national origin, age, disability, genetic information, political affiliation, military service, or other status protected by law.

PFS is committed to providing equal employment opportunities to all applicants. If you require a reasonable accommodation during the application or interview process, please contact us sonable accommodations are available to ensure applicants with disabilities have equal access to the hiring process, in accordance with the Americans with Disabilities Act (ADA) and applicable laws.

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