Associate Scientist - Cellular Model

Overview

The Associate Scientist will serve as the platform lead for functional cellular assays and high-content screening projects at the Single Cell Biology Laboratory (SCBL) within The Jackson Laboratory for Genomic Medicine, ensuring the timely delivery of high-quality, robust data. The SCBL is a core facility supporting the scientific research community with cutting-edge single-cell technologies, including dissociative single-cell omics, spatial omics, and high-content screening.

This role is central to the lab's functional biology and screening capabilities, requiring deep expertise in advanced cell culture systems, strong project coordination, and effective communication with scientific stakeholders.

• Act as the technical expert for functional cellular workflows, from experimental design and culture optimization to assay execution, data quality control, and workflow development.
• Leverage a strong background in cell biology and advanced culture systems to support and expand capabilities in 2D and 3D cell culture, organoids, co-culture assays, and iPSC-based models.
• Employ live-cell imaging, high-content or high-throughput screening, and laboratory automation or liquid handling systems as part of project execution.
• Collaborate with internal and external investigators to design and execute complex experiments, maintain high-quality standards across projects, and contribute to the development of innovative functional assays within the SCBL.

• Required
  
  Education:
  
  PhD in Biology, Molecular Biology, or a related scientific field.
• Experience:
  
  2–4 years of experience in a core facility or 4+ years in a research laboratory.
• Molecular & RNA Biology:
  Deep understanding of RNA and molecular biology principles and related assays.
• Cellular Models
  
  Experience:
  
  2D/3D mammalian cell culture, iPSCs/progenitor differentiation, and derivation of primary cell lines (2D and organoids).
• HCS/HTS:
  Experience with high-throughput cell assays (96-, 384-, or 1536-well formats) for drug screens, differentiation and perturbation assays, live imaging, and biochemical analysis.
• Liquid Handling and Automation:
  Familiarity with liquid handling and automation instruments used for HCS/HTS screens.
• Sample Handling:
  Experience with tissue processing, sectioning, handling, and immunohistochemistry (IHC).
• Documentation:
  Experience writing SOPs and familiarity with LIMS and ELN.
• Operational
  
  Skills:
  
  Project and lab management experience, including stock management, inventory, and instrument uptime.
• Soft Skills:
  
  Excellent communication, interpersonal, and presentation skills; ability to work effectively in interdisciplinary teams.

• Education:
  
  PhD preferred.
• Technical Breadth:
  Knowledge of spatial genomics technologies (e.g., Xenium, Visium, MERFISH, seqFISH).
• Single-Cell
  
  Experience:
  
  Hands-on experience with single-cell technologies (e.g., 10x Chromium, SMART-seq, split-and-pool methods).
• Imaging-Based Spatial Genomics:
  Experience with FISH-based platforms (Xenium, MERFISH, seqFISH).
• Biopharma Industry
  
  Experience:
  
  Familiarity with industry-standard workflows in biotechnology or pharmaceutical sectors.
• Histology Expertise:
  Experience in histopathology and tissue/microtissue processing.
• Development:
  Track record in technology development or assay optimization.

Pay Range: $69,711 - $90,624, salary determined by experience.

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies decades of genetics expertise to understand human disease, advance treatments, and provide data, tools, and services to the global biomedical community. For more information, please visit www.jax.org
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The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.