Software Test Engineer

Work Schedule:

Monday – Friday (with flexibility to meet operational needs), on-site or hybrid (minimum 2d per week onsite)

Location
:
On-Site in Boulder, CO (Foresight Dx business unit, a Natera company)

Foresight Diagnostics is a molecular diagnostics company pioneering non-invasive cancer detection through highly sensitive, cell-free DNA-based liquid biopsy technologies. Our proprietary methods - originally developed at Stanford University - are designed to detect smaller tumors earlier and enable more personalized treatment strategies for patients with cancer.

We sit at the intersection of molecular biology, bioinformatics, and next-generation sequencing (NGS), and we translate rigorous science into clinically meaningful solutions. Following our acquisition by Natera, we now combine the agility of a mission-driven startup with the scale and resources of a global leader in cell-free DNA testing. It’s an exciting moment to join us.

Headquartered in Boulder, Colorado, our team operates in a high accountability, collaborative environment where quality and continuous improvement aren’t just values - they’re how we work every day.

Design, develop, and execute test cases based on software requirements, functional specifications, and user needs for laboratory systems

Perform manual and/or automated testing to validate software functionality, data integrity, and workflow performance in a CLIA-regulated environment

Partner closely with laboratory operations teams to understand end-to-end workflows and translate them into effective test scenarios

Identify, document, and track software defects; collaborate with engineering teams to troubleshoot and resolve issues

Support validation and verification activities for new software releases, system upgrades, and process changes in accordance with CLIA, CAP, NYSDOH, and internal quality standards

Ensure traceability between requirements, test cases, and validation documentation

Participate in risk assessments and impact analyses related to software changes affecting laboratory operations

Contribute to the development and continuous improvement of software testing strategies, SOPs, and documentation practices

Support audits and inspections by maintaining clear, thorough, and compliant testing documentation

Act as a quality advocate, ensuring software supports accurate, reliable, and timely patient testing results

Partner with Operational Excellence to align test strategies with process design, workflow optimization, and scalability initiatives.

Provide input into system requirements and user stories based on laboratory workflow expertise and testing insights.

Support critical feedback loops to ensure continuous improvements to software systems.

Support change management efforts by assessing downstream operational impact of software releases and enhancements.

Bachelor’s degree in a scientific discipline (e.g., Biology, Molecular Biology, Bioinformatics) or related field, or equivalent experience

2+ years of experience in software testing, quality assurance, or validation, preferably in a regulated environment

Familiarity with NGS workflows and/or clinical laboratory operations (CLIA, CAP, or equivalent)

Experience writing and executing test cases based on requirements and specifications

Strong attention to detail and ability to identify edge cases and failure modes

Excellent documentation skills with a focus on clarity, completeness, and compliance

Demonstrated ability to translate complex operational workflows into structured test scenarios and validation strategies.

Preferred Qualifications:

Experience testing LIMS, LIS, or other laboratory software systems

Knowledge of software development lifecycle (SDLC) and validation frameworks (e.g., CSV, GxP)

Experience working in high-complexity molecular diagnostics or MRD testing environments

Familiarity with data validation, NGS file formats (e.g., FASTQ, BAM, VCF), and/or bioinformatics pipelines

Exposure to test automation tools or scripting (e.g., Python, SQL)

Experience working cross-functionally with engineering, bioinformatics, and quality teams

Exposure to regulated change control processes and…