Vice President, Global Medical Operations

About Stoke:

Stoke Therapeutics(Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.

Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit

The Vice President, Global Medical Operations will build and lead the operating model, infrastructure, governance, and execution capabilities that enable Global Medical Affairs to deliver its strategy with quality, speed, consistency, and compliance. Reporting to the SVP, Head of Global Medical Affairs, this leader will partner across Medical Affairs, Finance, Program and Alliance Leadership, Clinical Development, Regulatory, Commercial, Legal, Compliance, Procurement, Information Technology, and regional teams to translate medical strategy into integrated plans, establish scalable processes and systems, optimize resources and vendors, and provide transparent performance insights.

The role is accountable for operational excellence across the global medical portfolio, including annual and long-range planning, budget and resource management, field medical operations, med comms and congress operations, governance, technology enablement, policy and procedure management, and launch readiness.

• Define and lead the Global Medical Affairs operating model, translating functional and asset strategies into integrated annual and long-range operational plans, milestones, resource requirements, dependencies, and performance measures.
• Serve as a strategic adviser to the SVP, Head of Global Medical Affairs and the Medical Affairs Leadership Team on organizational priorities, capacity, investment choices, operating risks, and execution trade-offs.
• Own the Global Medical Affairs budget, forecast, headcount, and resource-allocation processes; partner with Finance and functional leaders to improve planning accuracy, manage commitments, and direct investment to the highest-priority medical objectives.
• Provide enterprise oversight of Medical Affairs funding and giving processes, including independent medical education grants, scientific and educational sponsor ships, charitable contributions, fellowships, and other external funding requests; establish transparent governance, funding criteria, decision rights, review committees, and appropriate separation from promotional activities in partnership with Medical, Legal, Compliance, Finance, and Procurement.
• Oversee the end-to-end lifecycle and financial stewardship of grants and sponsor ships—from intake, eligibility screening, objective review, contracting, and payment through milestone tracking, reconciliation, outcomes reporting, close-out, disclosure, and records retention—ensuring consistent documentation, audit readiness, budget visibility, and compliance with applicable laws, regulations, industry codes, and company policies.
• Lead the functions’s oversight of vendor and agency operating model, including ongoing performance management, quality oversight, and consolidation opportunities in…