Postdoctoral Fellow

National Cancer Institute, Frederick, MD

Scientific focus area:
Chemical Biology, Immunology, Molecular Biology and Biochemistry

The National Cancer Institute's Chemical Glycobiology Section is seeking a postdoctoral fellow to join the Gildersleeve laboratory. The goal of our research program is to discover, evolve, and use carbohydrate-binding antibodies for basic research and clinical applications. Cells are covered in carbohydrates, and the carbohydrates produced by a cell change significantly during the onset and progression of cancer, resulting in the display of numerous tumor‑associated carbohydrate antigens.

These carbohydrates are useful targets for vaccines, diagnostics, and therapeutic agents. Our lab develops new strategies to discover monoclonal antibodies that target these carbohydrates and new approaches to engineer and evolve antibodies.

We use a variety of approaches and techniques within these projects, including molecular biology, biochemistry, single‑cell sequencing, protein chemistry, and a carbohydrate antigen microarray that provides a unique tool for high‑throughput profiling of antibody selectivity and affinity.

• Discover and develop carbohydrate‑binding monoclonal antibodies.
• Engineer and evolve antibodies for improved selectivity and affinity.
• Apply single‑cell sequencing and protein chemistry techniques to study antibody–carbohydrate interactions.
• Use carbohydrate antigen microarrays for high‑throughput antibody profiling.

• Experience in antibody discovery, protein engineering, glycobiology, or directed evolution.
• Strong background in molecular biology, biochemistry, or related fields.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals, except individuals from a previously mentioned list.