Sr. Research Associate, Mass Spectrometry

PRIMARY FUNCTION

Conducts mass spectrometry methods to support research and bioforensic casework using LC-MS/MS and MADLI TOF instruments to identify and characterize protein and small-molecular weight biological toxins in samples for the NBFAC. Develops, executes and evaluates mass spectrometry methods for the identification and characterization of toxins in forensic samples under the ISO 17025 Standard.

• Participates in the development, validation, and conduct of mass spectrometry methods and assays for identifying and characterizing biological threat agents including proteins and small molecular weight toxins.
• Operates, maintains, and troubleshoots lab equipment such as MALDI TOF, UPLC, nanoLC, triple quadrupole and orbitrap mass spectrometers.
• Develops protocols, troubleshoots instrumentation issues, task‑specific procedures and Standard Operating Procedures (SOPs).
• Serves as a lead on mass spectrometry projects who anticipates issues and identifies opportunities to improve technical and team results.
• Maintains accurate records of the processing and analysis in a computerized Laboratory Information Management System (LIMS).
• Serves as a mentor who trains technical staff members on safe and compliant procedures for BSL‑2 laboratory access, toxin analysis of bioforensic samples and process documentation in LIMS.
• May be appointed as a Lab Space Manager (LSM), and/or Biological Select Agents and Toxins (BSAT) designee.
• Willingness to adapt to new work assignments, and perform assignments outside area of expertise, while managing resources efficiently.
• Works on assignments requiring considerable judgment and initiative, while understanding the implications of work and making recommendations for solutions.
• Receives little instruction on daily work, general instructions on newly introduced assignments, and has the ability to mentor personnel within the group, while identifying and communicating promptly and with recommended solutions.
• Participates in the testing and evaluation of new technologies and protocols including writing and updating NBACC SOPs, work instructions and forms to improve NBACC’s ability to serve its customers.
• Identifies departures from the Quality Management System (QMS) and initiates actions to investigate and prevent such occurrences.
• With minimal supervision, operates, maintains, and characterizes the performance of the equipment ensuring the reagents and supplies are maintained and used properly.
• Develops techniques, prepares samples and performs test according to appropriate SOPs.
• Serves as a member of a team in developing, validating, and maintaining methods for identifying and characterizing biological threat agents.
• Must be a team player, communicate clearly, be open to hearing ideas and suggestions from others, and exercise empathy and patience with colleagues.
• Must have the ability to multi‑task, maintain composure under pressure, and utilize effective time management skills to prioritize tasks.
• Must be a self‑starter driven by an eagerness to succeed, maintain flexibility, adapt to change in a productive and positive manner, learn new concepts, and utilize critical thinking to resolve complex problems.
• Maintains appropriate records.
• Performs other duties as assigned/authorized.

• Bachelor of Science (or equivalent) in a scientific discipline and a minimum of 6 years related experience or a Master’s degree and a minimum of 4 years of experience.
• Experience with mass spectrometry instrumentation such as LC-MS/MS and MALDI TOF. Proteomics and/or metabolomics experience is highly desirable.
• Experience with sample preparation techniques such as protein digestion, SDS‑PAGE, solid phase and liquid‑liquid extraction.
• Ability to analyze and interpret mass spectrometry data using informatics tools such as Proteome Discoverer, Compound Discoverer, Mass Hunter, Skyline, Max Quant, Frag Pipe and MS‑Dial. Proficiency with computer languages such as R or Python will be a plus.
• Advanced scientific proficiency in laboratory functions. Possesses the ability to identify issues and recommend solutions to laboratory protocols, procedures, and experimental…