Scientist II, Stem Cell Lab; IPSC

Job

Employee Type: exempt full-time

Division:
Laboratory Animal Science Program

Facility:
Frederick:
Ft Detrick

Location:

PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

The Laboratory & Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for laboratory and animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of husbandry, veterinary, state-of-the-art technology, and pre-clinical scientific services. LASP also provides primary support to the NIH Standardized Organoid Modeling (SOM) Initiative to address the need for validated, scalable, and reproducible organoid-based Novel Alternative Methods (NAMs) in biomedical research.

Our team provides technical infrastructure, operational integration, and specialized expertise to drive the development and optimization of organoid models of normal (non-cancerous) human tissues derived from a wide range of tissue types and donor sources.

• Designing, leading, and executing independent research projects focused on the development, optimization, and application of human induced pluripotent stem cell (iPSC)-based models, organoids, and other advanced in vitro systems to support the NIH Standardized Organoid Modeling (SOM) Initiative.
• Developing and optimizing differentiation protocols, cellular assays, and quality control strategies to generate reproducible, scalable, and biologically relevant stem cell-derived models.
• Designing experiments, analyzing and interpreting complex datasets, and integrating molecular, cellular, imaging, and functional data to advance scientific objectives.
• Collaborating with multidisciplinary investigators across the SOM Center and NIH to provide scientific expertise, develop experimental strategies, and support collaborative research projects.
• Contributing to grant applications, technical reports, manuscripts, presentations, SOP development, and scientific communications.
• Mentoring research associates, trainees, and junior scientists while fostering a collaborative and innovative laboratory environment.
• May supervisor junior level research staff
• Assisting with laboratory management, including implementation of new technologies, oversight of laboratory resources, and ensuring compliance with biosafety and quality standards.
• Remaining current with advances in stem cell biology, developmental biology, organoid technologies, and regenerative medicine to identify and implement emerging methodologies.

• Possession of PhD from an accredited college/university according to the Council for Higher Education Accreditation (CHEA).
• In addition to the education requirement, a minimum of two (2) years of relevant postdoctoral or equivalent experience.
• Must possess basic Microsoft Office skills.
• Demonstrated expertise in mammalian cell culture, aseptic technique, and advanced molecular and cellular biology methodologies.
• Experience designing, executing, troubleshooting, and optimizing complex scientific experiments independently.
• Demonstrated experience with experimental design, statistical analysis, data interpretation, and scientific communication.
• Strong organizational and project management skills with the ability to lead multiple projects simultaneously.
• Excellent written and verbal communication skills, including preparation of manuscripts, technical reports, and scientific presentations.
• Ability to obtain and maintain a security clearance.

• Demonstrated expertise with human iPSC reprogramming, culture, characterization, genome editing, and directed differentiation.
• Experience…