Sr. Network and Infrastructure Engineer Fremont, CA

Overview

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest time points, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development.

Personalis is based in Fremont, California.

Onsite:
Monday, Tuesday & Thursday

Summary:

We are seeking a highly skilled and versatile Senior Network & Infrastructure Engineer to join our growing team. This role is designed for a technical "bridge" builder—someone who possesses deep expertise in high-performance networking (HPC) and Cisco security, but who is also comfortable managing a modern, hyperconverged infrastructure stack.

The successful candidate will lead the architecture and maintenance of our Cisco Nexus fabric, secure our perimeter with Next Gen firewalls, and support a robust environment consisting of VxRail, VMware, and petabyte-scale HPC storage. You will be equally at home in a CLI environment as you are performing hands-on hardware management within our colocation data centers.

Responsibilities:

Network & Security Architecture (60%)

• HPC Networking: Architect, deploy, and optimize Cisco Nexus switches within a High-Performance Computing (HPC) environment, ensuring low latency and high throughput.
• Security & Firewalls: Full lifecycle management of Cisco Next Gen Firewalls (NGFW). You must be proficient in configuring security policies, routing, and VLAN segmentation.
• VPN Management: Lead the setup and maintenance of VPN connections (Site-to-Site and Remote Access) on Cisco platforms.
• Circuit Operations: Oversee the provisioning, monitoring, and troubleshooting of network circuits and ISP handoffs.
• Cloud Connectivity: Act as a subject matter expert for hybrid-cloud networking, supporting connectivity between on-premise hardware and AWS/GCP (Direct Connect/Cloud Interconnect).

Infrastructure & Systems Management (30%)

• Virtualization: Administer and scale VMware clusters running on Dell Vx Rail hyperconverged infrastructure.
• HPC Storage: Support high-performance storage environments, specifically VAST Data and Dell Isilon
  , ensuring data availability for intensive workloads.
• Systems Administration: Provide tier-3 support for Linux (RHEL/Ubuntu/CentOS) and Active Directory environments.
• Enterprise Tech: Manage Cisco Meraki wireless and edge networking for corporate office connectivity.
• Data Protection: Ensure the integrity of the environment through rigorous backup schedules and disaster recovery testing.

Physical Operations (10%)

• Data Center Ops: Perform hardware installations (Rack & Stack), cable management, and physical troubleshooting in Colocation (Colo) and Data Center environments.

Requirements:

• Experience: 5–8+ years of hands-on experience in network engineering and infrastructure.
• Cisco Mastery: Advanced knowledge of Cisco Nexus (NX-OS) and Cisco Next Gen Firewalls
  .
• Networking Fundamentals: Deep understanding of BGP, OSPF, VLANs, LACP, and VPN protocols (IPsec/SSL), WAN technologies.
• Hardware Knowledge: Proven experience with Dell server hardware and Vx Rail .
• Storage Proficiency: Exposure to high-performance file systems (VAST, Isilon).
• Physical: Ability to work on-site at data centers and office/labs, including lifting up to 50 lbs and working within server racks.

Preferred "Plus"

Skills:

• Cloud: Experience with AWS (VPC, Transit Gateway) or GCP (Cloud Router).
• Certifications: CCNP (Data Center/Security), VCP (VMware Certified Professional), or AWS Solutions Architect.
• Environment: Prior experience working in R&D, scientific, or lab environments.
• Automation: Experience with Python, Ansible, or Terraform for infrastructure-as-code.

The hiring range for this position is $150,000 to $170,000 per year, which may factor in various geographic regions. The base pay actually offered…