Sr. Software Engineer, Cloud Infrastructure

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Person alis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample.

In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited.

Personalis is based in Fremont, California.

We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud‑first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.

Monday, Tuesday, and Thursday

• Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
• Architect highly available, scalable, secure, and cost‑effective cloud solutions.
• Implement cloud networking, identity management, storage, compute, monitoring, and security services.
• Support integration between cloud and on‑premises infrastructure environments.
• Manage hybrid networking, VPNs, Direct Connect, Express Route, and secure connectivity solutions.
• Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
• Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
• Administer container orchestration platforms including Amazon EKS, Azure AKS, or self‑managed Kubernetes environments.
• Build and maintain containerized application platforms using Docker.
• Automate infrastructure provisioning, configuration management, and deployment processes.
• Support and optimize CI/CD pipelines using Git Hub Actions, Git Lab CI, Azure Dev Ops, Jenkins, or similar platforms.
• Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
• Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
• Ensure secure management of Protected Health Information (PHI) and sensitive business data.
• Partner with software engineering teams to optimize cloud‑native application architectures.

• Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
• 7+ years of infrastructure engineering experience.
• 5+ years of hands‑on cloud engineering experience in AWS, Azure, or GCP.
• 3+ years of Kubernetes administration and container platform management experience.
• Strong experience with Docker and containerized application deployment.
• Experience implementing Infrastructure as Code using Terraform or equivalent tools.
• Experience with Linux systems administration and cloud networking.
• Strong scripting and automation skills using Python, Power Shell, Bash, or similar languages.
• Experience supporting production‑critical environments with high availability requirements.

• AWS (EC2, EKS, RDS, S3, IAM, VPC, Route
  53, Cloud Watch, Lambda)
• Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
• Multi‑cloud and hybrid‑cloud architectures
• Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
• Monitoring services like Splunk, Datadog or other cloud‑native monitoring tools

• Cloud Architecture & Engineering
• Kubernetes Administration
• Docker & Container Platforms
• Infrastructure Automation
• Dev Ops & CI/CD
• Cloud Security & Compliance
• Site Reliability Engineering (SRE)
• Disas…