Senior Scientist, Advanced Technologies

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care throughout the patient journey. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest time points, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development.

Personalis is based in Fremont, California.

Days Onsite:
Monday - Friday

Personalis is a genome‑scale diagnostics company with a mission to pioneer genome guided medicine. Our priority is to obtain the most accurate genetic data from each sample, and then to draw the most reliable medically‑focused conclusions from these. Our tests are based on whole human genome and exome sequencing, conducted in our state‑of‑the‑art laboratory. We analyze results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms.

You will work with a world‑class, dynamic team of scientists, software engineers, assay developers, product managers, and clients applying our cutting‑edge cancer and immuno‑oncology solutions. As a Staff Scientist, you will contribute to the development of new protocols, optimize new and existing methods, as well as plan, execute, analyze, and interpret results from development projects and validation studies. You should be an energetic and hands‑on individual who has the technical background to identify issues and find effective solutions.

Your work will contribute to a new generation of genomics‑based precision medicine products in immuno‑oncology and cancer clinical trials, diagnostics, and therapeutics being used by pharma, biotech, hospitals and clinicians.

• Perform feasibility experiments to support early research and new product development.
• Design, execute and document development, equivalency, verification and validation studies.
• Stay current with the latest developments in NGS and molecular diagnostics, proactively determining which technologies can be leveraged to enhance and expand Personalis’ product portfolio.
• Identify problems in current processes and come up with troubleshooting approaches and solutions.
• Work cross functionally with the bioinformatics teams to plan experiments and analysis to validate novel procedures and analytics.
• Collaborate with the Product Development, Tech Transfer and Automation teams for the development and implementation of new products.
• Communicate complex data in a clear and concise manner to a diverse audience.
• Foster a highly collaborative and dynamic working environment through effective, two‑way communication.
• Support documentation efforts for laboratory procedures.
• Support and ensure compliance with all department and company policies and procedures.

• PhD with a minimum of 4 years of experience or MS with a minimum of 8 years of experience.
• Minimum of 2 years of industry laboratory experience with NGS technology and RNA/DNA manipulation.
• Passion for exploring new technologies and thinking creativity to solve problems.
• Strong written and verbal communication skills.
• Excellent organizational skills, with a proven ability to troubleshoot complex technical issues.
• Flexibility, multitasking, teamwork and self‑initiative are required to support simultaneous projects.
• Experience in biotech, clinical labs, lab automation, LIMS and/or bioinformatics is highly desired.
• Strong desire to work in a demanding, high‑energy, hands‑on startup environment.

The hiring range for this position is $132,000 to $165,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job‑related knowledge, skills, and experience among other factors. Our full‑time regular positions also include an annual performance‑based bonus (or a sales incentive plan) and long‑term…