Biological Scientist IV - Pulmonary

Classification

Title:

Biological Scientist IV

Classification

Minimum Requirements:

Bachelor's degree in biology or a related field and thirteen years of experience or Master's degree in biology or a related field with eleven year of experience. Doctoral degree in biology or related field with eight years of experience.

Job Description:

The Division of Pulmonary, Critical Care & Sleep Medicine is accepting applications for a Biological Scientist IV. The position will reside within the Division's Alpha-1 Antitrypsin Laboratory and will report directly to Dr. Karina Serban, the laboratory director and an experienced physician-scientist in the field of Alpha-1 deficiency and chronic obstructive pulmonary disease (COPD).

Human and murine tissue processing and epithelial cell isolation and precision cut lung slices (PCLS)-related Experiments

* Develop novel approaches and analytical tools as required to harvest and maintain epithelial cells and PCLSs cultures derived from human explanted lungs and murine lungs.

* Design and develop dose escalation studies involving alveolar organoids and PCLSs cultures in accordance with IRB and IBC protocols.

* Collect, dissect, examine and interpret results of human and murine epithelial cells and tissue harvest.

* Develop, organize and conduct immunofluorescence and FACS analysis and data interpretation.

* Design and direct metabolism assays (Seahorse), to include oversight of technicians performing testing, review and interpretation of results.

* Provide intellectual input as to troubleshooting strategies utilized in organoids and PCLS cultures.

Scholarly activities related to Alpha-1 Antitrypsin Deficiency and COPD research conducted in the lab

* Analyze and interpret data, prepare graphs and figures for meetings and grant submissions.

* Present data and manuscripts in weekly lab meeting and annually in divisional meetings.

* Design and direct ELISA testing for Alpha-1 Antitrypsin Deficiency to include oversight of technicians performing the testing, review and interpret the results.

* Participate in bio-product development to include initial designs, pilot experiments, and collaborating with the Office of Technology and Licensing for assurance of appropriate patents.

* Create or modify web-based tools and test potentially new software to provide statistical and computational tools for big data interpretation.

Managerial Duties

* Supervise other scientists and undergraduate students.

* Coordinate experiments involving human tissue harvest to include procedures in collaboration with lung transplant team and other research groups on campus.

* Interact and coordinate with off-campus collaborators samples shipments, common on-line meetings, and in-person visits.

* Prepare a quarterly report on the performance of the scientists and students, under direct supervision.