Senior DirectorVice President Preclinical Pharmacology
Listed on 2026-02-19
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Healthcare
Medical Science, Clinical Research -
Research/Development
Research Scientist, Medical Science, Clinical Research, Immunology Research
Benefits
- 401(k) matching
- Bonus based on performance
- Dental insurance
- Free food & snacks
- Health insurance
- Paid time off
Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as Senior Director or Vice President, Preclinical Pharmacology. This SD/VP will be responsible for integrating in vivo pharmacology, PK/PD, and toxicology into the company's R&D strategy, with a strong foundation in cardiovascular and metabolic disease biology to inform nonclinical development plans and translational strategy. This role guides programs from late research through IND/CTA submissions, ensuring alignment with regulatory and scientific standards, and will have a lasting impact on the company's scientific direction and future success.
Key Responsibilities- Preclinical Pharmacology Oversight:
Leverage disease biology knowledge to design, manage, and interpret pharmacology and PK/PD studies, and guide and oversee toxicology studies (GLP/non-GLP), to enable development candidate nomination and IND application. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages. - Cross-Functional Integration:
Lead cross‑functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans. - Strategic Program Leadership:
Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategies across the portfolio and drive new discovery initiatives grounded in scientific rigor and corporate strategy.
- PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline
- 10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical drug discovery and/or pharmacology
- Demonstrated ability as program lead to advance programs from lead optimization to IND approval; preference for experience with complex biologics, such as antibodies (multispecific, antibody‑protein fusions), and/or antibody conjugates (antibody‑drug conjugates with small molecule payloads such as cytotoxic agents, toxins or others, antibody‑oligonucleotide conjugates such as antisense oligos, siRNAs).
- Deep expertise in cardiovascular and/or metabolic disease biology, with working experience designing and interpreting disease‑relevant in vivo models.
- Solid working knowledge in bioanalysis, PK/PD, and DMPK.
- Sufficient understanding of toxicology principles to provide scientific oversight of GLP and non‑GLP toxicology studies conducted at CROs.
- Experience delivering high‑quality preclinical/nonclinical data packages for development candidate selection and IND application.
- Familiarity with FDA/EMA expectations for nonclinical data packages supporting biologics development.
- Experience across oncology and CVM therapeutic areas is a strong plus.
- Strong strategic thinking and scientific judgment with excellent problem‑solving capabilities
- Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences
- Strong interpersonal skills with the ability to motivate, influence, and lead cross‑functional teams in a matrixed environment
- Demonstrated ability to work collaboratively and influence at all levels of the organization
- Independent, self‑motivated leader with the ability to work in a fast‑paced, team‑based drug discovery and development environment
Salubris Biotherapeutics, Inc. (or Salubris Bio) is a clinical‑stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics for the treatment of cancer, cardiovascular, and metabolic diseases. We are advancing a robust complex biologics pipeline including antibody‑drug‑conjugate and antibody‑fusion programs, with a commitment to transforming patient outcomes through scientific excellence and innovation. We offer a competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits.
Salubris Bio is an equal opportunity employer committed to diversity and inclusion in the workplace.
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