Statistical Science Director V&I

What you'll do:

In this role you will be responsible for leading the strategic statistical thinking and contributions to the Development Plans, Regulatory Strategy, Health Technology Assessment, and Commercial Presentation for indications/projects within an AstraZeneca product team.

You will provide leadership to statistical staff on the indications/projects so that all work is carried out with regard to AstraZeneca standards and external regulations, develop design options, and provide high quality decision support to enable informed business decisions.

You will apply expert skills to investigate and apply novel statistical approaches for relevant statistical issues and regulatory guidance, and mentor and coach staff in the technical arena.

• Lead the statistical design and strategy to product development plans, preclinical studies, regulatory strategy, health technology assessment, and/or commercial activities as appropriate for the stage of the product.
• Lead the statistical content and ensure quality for study designs, documents, delivery, interpretation, and submission.
• Quantify the benefit, risk, value, and uncertainty of the emerging product profile and communicate these effectively within the team.
• Provide global leadership to others and direct project work delivered by internal and external staff.
• Partner with CROs to ensure delivery to quality and time.
• Represent AstraZeneca externally, which may include health authorities, advisory boards, conferences, workshops, and/or payer interactions.
• Maintain knowledge of statistical methodology in relevant areas and promote, investigate, and implement novel statistical approaches.
• Represent statistical strategy and decision‑making at internal governance including review boards, therapy area leadership teams, and ESPC/LSPC.
• Mentor/coach and support the technical education and training of Statistics staff.

• In-depth knowledge of technical and regulatory requirements with experience in pharma/healthcare.
• Stay up-to-date and implement novel statistical approaches.
• Experience with broad awareness of regulatory interactions and/or submissions.
• Excellent communication skills and ability to build strong relationships.
• Nationally recognized externally and invited to attend or speak at seminars and external meetings.
• Well‑rounded statistician with publications on a range of topic areas and publications resulting from external collaborations.
• Expert leadership role able to lead/direct work across a team.

This role requires an individual with outstanding technical skills, leadership, and the ability to guide and support multiple studies while fostering team development and project success.

• MSc/PhD in Statistics, Mathematics (with a substantial statistical component), or a recognized equivalent to a statistics MSc.
• Proven track record of independent leadership.
• 5 years of experience in clinical trials critical for this role.
• Recognized for exemplary technical skills and expert leadership role or national recognition as a statistical technical expert.
• Demonstrated ability to provide cross‑study support, overseeing, aligning, and providing technical support for multiple studies.

• Experience in Vaccines & Immunotherapy is a strong asset but open to other therapeutic areas.
• Implemented simulation programming for sample size calculations or interim analyses.
• Experience with business development opportunities, such as in‑licensing, would be beneficial.
• Proficiency in programming languages such as SAS, R, and Python.
• Strong project management skills.
• Excellent communication skills, especially in relation to project management and stakeholder engagement.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace, and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while…