Multiplex & IF Staining Neurology Scientist

Job Title:

Multiplex & IF Staining Neurology Scientist

Location:

Gaithersburg, MD

Duration: 3-4 Month Contract with potential of exp

• Perform multiplex IF staining on FFPE tissue sections
  , including complex, high‑parameter antibody panels specific to neurological targets and pathways
  .
• Operate Cell DIVE™ or comparable high‑plex imaging platforms
  , including image acquisition, optimization, and troubleshooting.
• Execute image pre‑processing, segmentation, quality control, and multiplex imaging analysis workflows
  .
• Evaluate staining quality, signal specificity, background, and reproducibility across neuro tissue samples.
• Perform routine maintenance, calibration, and performance checks on imaging instrumentation.

• Prepare and process FFPE neural tissue samples
  , including embedding, sectioning, and slide preparation.
• Conduct automated and manual IHC staining (Ventana, Leica, Dako, etc.), with a focus on neuroscience biomarkers
  .
• Optimize staining protocols for difficult neural tissues and complex multiplex panels.
• Ensure accurate documentation, sample tracking, and traceability throughout lab workflows.

• Perform quantitative multiplex imaging analysis for spatial biology datasets derived from neurological tissues.
• Review and QC imaging outputs to ensure scientific rigor and reproducibility.
• Support interpretation of spatial patterns, co‑localization, and biomarker expression relevant to neuro biology.
• Facilitate structured data handoff to pathology, translational science, and bioinformatics teams.

• Participate in cross‑functional meetings with translational, pathology, biomarker, and neuroscience stakeholders.
• Contribute scientific input to study design, assay optimization, and troubleshooting activities.
• Balance hands‑on wet‑lab work with scientific discussions and planning meetings
  , ensuring alignment with program objectives.
• Maintain high‑quality documentation in accordance with the clients lab standards and regulatory expectations.

• BS or MS in Biology, Neuroscience, Molecular Biology, Pathology, Biomedical Sciences
  , or related field.
• Hands‑on experience with IHC and multiplex IF staining
  , preferably using automated platforms.
• Demonstrated experience handling FFPE tissues
  , ideally neural or CNS‑derived samples.
• Familiarity with microscopy, image acquisition, and basic image analysis principles.
• Strong attention to detail and ability to execute standardized laboratory workflows.

• PhD in Neuroscience, Immunology, Pathology, Molecular Biology, Biomedical Engineering
  , or related discipline.
• Extensive experience with multiplex IF staining
  , high‑plex panel development, and optimization.
• Proven expertise with high‑plex imaging technologies (Cell DIVE™, Pheno Cycler, MIBI, Cos Mx, etc.).
• Strong background in multiplex imaging analysis and spatial biology
  , preferably applied to neurology programs.

• Experience with multiplex image analysis software (HALO, QuPath, Cell Profiler, or similar).
• Familiarity with neurological disease biology
  , CNS biomarkers, or translational neuroscience research.
• Ability to troubleshoot staining challenges, imaging artifacts, or analytical inconsistencies in neural tissues.
• Experience working in GLP‑like or highly structured laboratory environments
  .

• Strong communication skills with the ability to engage in both technical lab work and scientific discussions
  .
• Comfortable managing time between wet‑lab execution and collaborative meetings
  .
• Self‑directed, organized, and able to prioritize deliverables in a fast‑paced research setting.
• High scientific rigor with excellent documentation practices.