Infectious Disease In Vivo Cancer Vaccine Scientist

Job Description

Hereat Astra Zenecayou ’llhave the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance worldhealth, andhelp fight and cure disease. As aScientistin the Virology and Vaccines Discovery groupintheearly

Infectious Diseasetherapeutic areabasedin

Gaithersburg, MD,you’llplay a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

The Virology and Vaccines Discoverygroup atAstraZenecaisdiscoveringand developing biologics and vaccines targeting key viral pathogens, including respiratoryand chronicviruses.

Weareconsistentlypushing the boundaries of science to deliver life-changing medicines to patients.

Our deepexpertiseinvaccines and immunologyenables our ability to advancenovel therapeutic approaches and technologies to prevent and treat infectious disease.

Wehaveanindustry-leadingpipelineandoffer a unique and strong collaborative network as part of the AstraZeneca family.

Currently, we areseekinga highly motivated and broadly skilled bench scientist within vivotechnicaland immunologyexpertiseanda track recordof scientific achievement to join the Virology and Vaccine Discovery group at AstraZeneca in Gaithersburg, MD. The scientist will be a key member of a team focused on developing next-generationcancervaccinesthrough the drug discovery process. The position requires a strong interest invivarium and laboratory bench worktodriveprojects forward.

AstraZenecahas a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

• Design, manage,and conduct in vivo rodent studies to support the development ofcancervaccines targetinghosttumorantigens andendogenous retroviruses

• Performimmunizations, tumor implantations,andnecropsies, collect and process tissues and blood products for downstream immunological assays

• Conduct in vitro immunological assays to support the development of vaccines, including flow cytometry, ELISpot, and ELISA

• Design, execute and interpret results from animal studies to characterize biologic therapies directed againsttumor antigens aspart of vaccine antigen discovery efforts

• Work collaboratively with colleagues across the organization (e.g.protein engineering, bioinformatics, pathology, and translational medicine) to drive projects towards successful completion

• B.S. in Virology, Molecular Biology, Microbiology, Immunology, Cell Biology, or related scientific discipline with2+ years of experience or

• M.S. in Virology, Molecular Biology, Microbiology, Immunology, Cell Biology, or related scientific discipline

Broad experiencedesiredinoncology,immunology, and vaccinology

• Advanced knowledge ofanimal handling techniques, including intramuscular, intranasal, subcutaneous,and intravenous immunizations,andeuthanasia

• Advanced knowledge of tumorharvesting andother tissue processing,i.e.lymph nodesandspleen

• Experience with mouse tumor modeldevelopmentisstronglydesired

• Knowledge of flow cytometrysample acquisition and data analysisisstronglydesired

• Experience with automation is desired

• Ability to multitask and prioritizeamongnumerousprojects

• Strong interpersonal and collaborative skills together with evidence of having used these tosupport problem solving and delivery in a team-oriented, collaborative environment

• Ability to work in a collaborative, fast-paced environment while planning and meeting timelines

• Proven track recordof success in your research and experience preparing written scientificreports (e.g.manuscripts) and oral presentations (e.g.slides, posters)

• Strong verbal and written communication skills

Must be able to understand,conduct and interpret results of technically challenging experiments with supervision.

Ability to work independently as well as part of team is expected.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation,…