Scientist (In Vivo), Immunology​/Pharmacology

Join us to build differentiated medicines in immunology

At
Astra Zeneca , we are investing in the next wave of
immunology and autoimmune disease
innovation. We are looking for a strong
in vivo scientist
who wants to do more than run studies: someone who can generate robust data, think critically about biology, and help shape programs from
target validation through early development
.

This role sits within our
Early Respiratory & Immunology
organization and is ideal for a scientist who brings deep hands-on
in vivo pharmacology
expertise, thrives in a collaborative research environment, and is motivated by translating complex immunology into decisions that matter for patients. You will contribute to programs in areas such as
SLE, arthritis, and other immune-mediated diseases
, working closely with project teams to answer mechanistic and translational questions with high scientific rigor.

This is not a purely executional in vivo role. We are looking for someone who can combine
technical excellence
,
disease insight
, and
sound experimental judgment
. The successful candidate will have the opportunity to influence study design, interpret data in biological context, and contribute meaningfully to portfolio progression.

You will be positioned to:

• Own critical in vivo study execution
  across disease and mechanistic models in immunology
• Generate translationally relevant data
  that helps teams make faster, better decisions
• Partner cross-functionally
  with pharmacology, immunology, translational sciences, and project leadership
• Grow into study leadership
  and become a go-to expert for in vivo immunology approaches
• Contribute to a high-impact portfolio
  focused on serious diseases with substantial unmet need

You will design, execute, and interpret
in vivo studies
that support discovery and early development programs in immunology. You will work with a high degree of independence while collaborating closely with colleagues across functions.

Key responsibilities include:

• Designing and running in vivo studies
  in disease and mechanistic models relevant to autoimmune and inflammatory biology
• Administering candidate molecules
  and collecting blood, tissue, and other biological samples with strong technical proficiency
• Supporting biomarker strategy
  through sample collection, assay planning, and data interpretation
• Processing tissues and generating downstream data
  using approaches such as
  flow cytometry, immunofluorescence, multiplex immunoassays, RNA isolation, and qPCR
• Evaluating and interpreting primary data
  to identify meaningful pharmacology and mechanism-related insights
• Preparing clear study summaries and reports
  that enable project teams to act on results
• Maintaining the highest standards
  in
  animal welfare, ethics, documentation, data integrity, and study quality
• Depending on experience,
  leading in vivo study activities
  for discovery and early development programs

We are especially interested in candidates who bring a combination of the following:

• Strong hands-on in vivo expertise
  with confidence operating independently in a research setting
• A solid grounding in immunology and pharmacology
  , with the ability to connect experimental outcomes to disease biology
• Experience generating high-quality samples and data
  across both in vivo and ex vivo workflows
• Scientific curiosity and critical thinking
  , not just technical execution
• Clear communication skills
  , including the ability to explain data, caveats, and implications to diverse stakeholders
• A collaborative mindset
  and the maturity to work productively across disciplines

• BSc required
  in
  immunology, pharmacology, biology, or a related discipline + 5 years of experience
• MSc preferred
  , or equivalent depth of hands-on scientific experience + 3 years of experience
• Proven experience in
  in vivo research
  using animal models
• Demonstrated capability in
  tissue collection and sample processing
• Experience with one or more relevant techniques, including
  flow cytometry and analysis, immunofluorescent staining, multiplex ELISA or related immunoassay platforms, RNA isolation, and qPCR
• Good understanding of
  immunology, pharmacology, and physiology
• Experience in
  data analysis, study documentation, reporting, and archiving
• Familiarity with
  statistical methods
  and quality-focused experimental practice
• Strong written and spoken
  English communication skills

Candidates will stand out if they have experience in one or more of the following areas:

• Industry experience
  in
  biopharma
  or
  drug discovery
• Research in
  autoimmune or inflammatory disease
  , such as
  SLE, arthritis, or IBD
• Experience with
  specialized in vivo techniques
  or development/optimization of in vivo models
• Use of
  translational biomarkers
  to bridge preclinical findings to clinical questions
• Exposure to working in
  matrixed project teams
  where data drives portfolio decisions

In this position, success means consistently delivering
reliable, decision-enabling data
, proactively identifying…