Research Scientist - Wnt Signaling in Hematopoietic Stem Cell Development and Cancer

Full time Research Scientist - Wnt Signaling in Hematopoietic Stem Cell Development and Cancer

Van Andel Institute (VAI) is a nonprofit biomedical research and science education institute dedicated to uncovering disease mechanisms and translating discoveries into therapeutic solutions that improve lives. We are looking for a full‑time Research Scientist to join the Grainger Laboratory.

The Grainger Lab studies how different Wnt ligands select their Frizzled receptors and how those signals guide hematopoietic stem cell function. Our work employs zebrafish and cell‑culture model systems, including induced pluripotent stem cells, to generate hematopoietic lineages. Techniques routinely used in the lab include molecular cloning, western blotting, confocal imaging, flow cytometry, protein purification, and more. We also develop and implement new methodologies as needed.

You will be expected to initiate and carry out projects, generate data, interpret results, and contribute to the lab’s ongoing work. You will collaborate with postdoctoral fellows and may mentor graduate students or interns. Your work should help advance grant and manuscript production.

• Chance to work in a collaborative, productive environment with opportunities to mentor students and interns.
• A thriving, hard‑working, and fun workplace.
• Rigorous experimental approaches and the application of new techniques.
• NIH R35 grant funding in addition to strong base funding from VAI.
• Opportunity to work with motivated postdoctoral fellows who are part of VAI.
• Grainger is within a group of highly collaborative scientists with expertise in diverse cell types and communication mechanisms.

• PhD degree in developmental biology, cell biology, molecular biology, or related field.
• Postdoctoral research experience with a proven track record (publications) in molecular biology techniques.
• Experience mentoring junior scientists and proven leadership skills.
• Proficiency in confocal microscopy, zebrafish husbandry and manipulation, molecular cloning, pluripotent stem cell culture, and molecular biology.
• Strong theoretical background in molecular and cell biology; knowledge of developmental biology and/or hematopoietic stem cells is an asset.

• CV
• Cover letter describing why you are interested in the lab and how you envision yourself fitting into our scientific vision.
• Names and contact information for three professional references.

All full‑time employees of Van Andel Institute receive a comprehensive benefits package effective Day One. This salaried position will be based on experience and skills.

Van Andel Institute is located in downtown Grand Rapids, a cosmopolitan area with small‑town warmth, philanthropic community, and sustainability focus. The institute sits on the banks of the Grand River and offers a safe, walkable downtown with restaurants, theatres, museums, sports, and concerts.