Senior Scientist, Process Development

Overview

Use Your Power for Purpose. We are seeking a creative, highly motivated chemist with experience in biocatalysis to join Chemical Research and Development (CRD) in Groton, Connecticut. The successful candidate will help develop innovative enzymatic processes for key precursors used in the synthesis of active pharmaceutical ingredient (API) candidates across our portfolio. This role requires scientific rigor, a strong interest in advancing biocatalysis technologies, and a demonstrated ability to deliver high‑quality technical results.

• Independently develop biocatalytic platforms, protocols, and workflows aligned with process chemistry objectives and emerging technology advances.
• Apply expertise across enzyme classes relevant to pharmaceutical biocatalysis, including enzyme screening, protein engineering, reaction kinetics, and reaction scale‑up.
• Design and execute experiments independently with clear objectives, and maintain accurate, compliant documentation in electronic laboratory notebooks.
• Contribute innovative ideas for enzymatic and organic transformations for API synthesis and maintain current knowledge of the biocatalysis and synthetic chemistry literature.
• Coach, mentor, train, and supervise staff when assigned, and support recruiting activities as needed.
• Collaborate effectively with chemists, analysts, and chemical engineers across Research and Development and manufacturing to design novel enzyme‑enabled processes.
• Prepare research reports, technical presentations, and external publications.

• Minimum Requirements:
  PhD in Chemistry or Chemical Biology with 0–5 years of pharmaceutical industry experience.
  Hands‑on experience applying enzymes in a laboratory setting and familiarity with the development of pharmaceutical processes using biocatalytic methods.
• Preferred Requirements:
  Expertise in using a broad range of enzymes in organic chemistry.
  Experience designing and optimizing biocatalytic reactions, conducting high‑throughput screening in multi‑well plates, and developing new enzyme platforms.

• Ability to work in a standard laboratory environment, including conducting experiments in a fume hood.
• Ability to perform complex data analysis.
• Strong communication skills and effective collaboration within multidisciplinary teams.
• Self‑awareness and willingness to seek input from others to improve ideas and problem‑solving.
• Adaptability in response to changing project priorities.

Occasional domestic and international travel (0–5%) may be required to support technology development, clinical manufacturing, and technology transfer to commercial manufacturing. Relocation support available. Work location assignment:
On Premise.

The annual base salary for this position ranges from $93,600.00 to $. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share‑based long‑term incentive program.

We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

Learn more at Pfizer Candidate Site – U.S. Benefits.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.

Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States.

Sunshine Act:
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. Those payments may be reported to the government. If you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.

For inquiries, contact your Talent Acquisition representative.