Cryo-Electron Microscopy Specialist

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Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

• 100% Medical, Dental & Vision Coverage for Employees
• Paid Time Off and Paid Holidays
• 401K match up to 5%
• Educational Benefits for Career Growth
• Employee Referral Bonus
• Flexible Spending Accounts:
• Healthcare (FSA)
• Parking Reimbursement Account (PRK)
• Dependent Care Assistant Program (DCAP)
• Transportation Reimbursement Account (TRN)

We are looking for a skilled Cryo-electron microscopist to join the Research Technologies Branch (RTB), Electron Microscopy Unit (EMU). This position is based at Rocky Mountain Laboratories (RML) in Hamilton, Montana. In this role, you’ll work closely with scientists in a collaborative, fast-paced environment, helping generate high-quality data that supports infectious disease research.

This is a hands‑on position for someone who enjoys both the technical side of electron microscopy and the collaborative nature of working with different research groups. If you have strong cryo‑EM experience and are excited about learning and applying newer approaches like room‑temperature EM, FIB-SEM, and cryo‑EM, this could be a great fit.

• Perform negative staining on purified proteins to evaluate sample quality.
• Prepare biological samples for cryo-EM (plunge freezing) and perform imaging and analysis.
• Operate and help maintain TEM and other ancillary instruments, including troubleshooting when needed.
• Work closely with NIAID investigators to plan experiments, interpret results, and solve technical challenges.
• Help bring new capabilities online, including techniques like CLEM, FIB-SEM, and cryo-EM.
• Keep clear, well‑organized records in line with NIH standards for rigor and reproducibility.
• Train and support other lab members or facility users in EM techniques and image processing.
• Contribute to the overall operation of the lab, including equipment upkeep and safety compliance.

• Master’s degree or higher in a relevant field (Cell Biology, Structural Biology, Biophysics, or similar).
• Solid understanding of EM sample preparation and imaging workflows.

Experience with, or strong interest in learning:

• Room temperature electron microscopy
• Correlative Light and Electron Microscopy (CLEM)
• Focused Ion Beam-SEM (FIB-SEM)
• Familiarity with image analysis tools.

• You’re a team player who enjoys working with a range of scientists and projects.
• You’re curious and motivated to learn new techniques and technologies.
• You’re organized, detail‑oriented, and take pride in producing high‑quality data.
• You can balance multiple priorities without losing track of the details.

Location:

Rocky Mountain Laboratories in Hamilton, Montana.

The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed…