Executive Director, Global Program Leader
Listed on 2026-08-12
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Management
Regulatory Compliance Specialist, Project & Program Management
Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life‑threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in‑vivo cell therapy approaches. Our research spans chimeric antigen receptor T‑cell (CAR‑T), T‑cell receptor (TCR‑T), natural killer (NK) cell‑based therapies, and other emerging platforms designed to transform the treatment of serious diseases.
From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting‑edge therapies for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta‑cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.
Legend Biotech is seeking an Executive Director, Global Program Leader as part of the Research & Development team based in Somerset, NJ
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The Executive Director, Global Program Leader (GPL) is a senior strategic leadership role responsible for the overall development, execution, and governance of Legend Biotech's in‑vivo CAR‑T programs.
Reporting directly to the President of R&D, the GPL serves as the single point of accountability for leading cross‑functional teams to define and execute integrated global development strategies from IND enabling through clinical proof‑of‑concept, late‑stage development, registration, and lifecycle management. The GPL ensures alignment of program strategy, timelines, resources, and operational execution across Research, Clinical Development, Regulatory Affairs, Translational Sciences, Technical Development, Manufacturing, Commercial, Business Development, and other key functions.
The successful candidate will combine strong scientific and clinical development expertise with exceptional leadership, strategic thinking, and execution capabilities to advance innovative in‑vivo CAR‑T therapies for patients worldwide.
Key Responsibilities- Partner closely with Clinical Development and Regulatory Affairs to design efficient development pathways that maximize speed to proof‑of‑concept, pivotal development, and global approvals.
- Guide critical regulatory interactions and major health authority milestones.
- Ensure readiness and alignment for INDs, CTAs, BLA/MAA submissions, and lifecycle management activities.
- Chair Global Program Teams and provide leadership across all functional areas involved in program execution.
- Foster effective collaboration among Research, Translational Medicine, Clinical Development, Regulatory Affairs, Biometrics, CMC, Quality, Manufacturing, Commercial, Finance, and Business Development.
- Drive cross‑functional problem‑solving and ensure timely resolution of strategic and operational risks.
- Establish clear governance processes, decision frameworks, and accountability mechanisms.
- Present program strategies, risks, and recommendations to executive leadership and governance committees.
- Lead preparation of development scenarios, investment analyses, milestone recommendations, and portfolio reviews.
- Provide regular updates to senior management on program status, emerging opportunities, and critical risks.
- Ensure effective risk management and contingency planning throughout development.
- Represent Legend Biotech in interactions with external partners, collaborators, investigators, key opinion leaders, and other stakeholders.
- Support business development assessments, diligence activities, and partnership opportunities related to in‑vivo CAR‑T technologies.
- Serve as a scientific and strategic ambassador for Legend's in‑vivo CAR‑T platform.
- Build a high‑performance, patient‑focused, and collaborative program culture.
- Mentor and develop program management and cross‑functional team members.
- Champion innovation, accountability, and operational excellence across development teams.
- MD, PhD, PharmD, or equivalent…
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