Senior Scientist - Immunology Biology

Summary

The Biology Department is seeking a self‑motivated, knowledgeable, and technically skilled immunologist with a deep understanding of inflammatory and autoimmune disease mechanisms. In this role, you will design, execute, and interpret experimental studies to demonstrate the mechanism of action for small‑molecule and biologic therapies. Senior scientists operate in a highly collaborative environment, working closely with colleagues across the organization to enable the progression of novel drug candidates from discovery into the clinic.

The successful candidate will lead elements of drug discovery programs by providing scientific insight, generating robust experimental data packages, and developing mechanistic models of disease to advance Arcus drug candidates. Senior scientists have opportunities to mentor junior scientists through hands‑on training, technical guidance, and feedback in experimental design, troubleshooting, and data interpretation. Senior scientists are responsible for the design, execution, and optimization of in vitro and in vivo model systems to support therapeutic hypotheses and confirm the mechanism of action for candidate molecules.

This role will contribute both intellectually and experimentally within a multidisciplinary team to regularly synthesize, interpret, and present results in internal forums and, as appropriate, external scientific venues.

• PhD in immunology or a related scientific discipline with 3+ years of relevant industry experience.
• Deep understanding of inflammatory and autoimmune disease mechanisms demonstrated through scientific presentations and publications.
• Strong ability to identify, design, and fully analyze critical experiments, develop experimental next steps, and integrate new information to revise previous hypotheses.
• Extensive expertise in the isolation, culture, and functional evaluation of primary immune cells (mouse and human).
• Proficiency with immunoassay techniques including multi‑color flow cytometry, ELISA (or equivalent method) and western blot.
• Demonstrated expertise in the design and execution of murine models of inflammation including study design, tissue collection/processing, and ex vivo immunophenotyping to support the mechanism of action for drug candidates.
• Strong collaboration and leadership skills—including cross‑functional teamwork, clear presentations, and mentoring of junior scientists.
• Well‑developed scientific communication skills with demonstrated experience preparing external scientific materials including conference abstracts, scientific posters, and manuscripts for peer‑reviewed publication.

This role will be based at our Hayward, CA location. The anticipated salary range for fully qualified candidates applying for this position is $160,000 - $175,000 USD annually. In addition to a competitive market‑based salary, Arcus offers the opportunity to participate in stock programs, a performance‑based bonus, and a comprehensive benefits package.

• Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk‑based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
• Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
• Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
• Must have correctible vision to perform duties of the job.
• Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
• Ability to lift heavy objects, possibly weighing up to 50 pounds.
• Position may require repetitive motion.
• May require working near blood borne pathogens.
• May require work in an environment where animals are used for teaching and research.
• Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
• Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
• May require extended or unusual work hours based on research requirements and business needs.
• Consistent with its obligations under the law, the company will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of their job.

Arcus Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Arcus is committed to the principle of equal employment opportunity for all employees and does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, non‑disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets