Senior Manager Manufacturing System Engineering - Bulk Drug Substance - Upstream

Amgen – Senior Manager Manufacturing System Engineering (Bulk Drug Substance – Upstream)

Join Amgen’s mission of serving patients living with serious illnesses. Since 1980, Amgen has pioneered biotech in our fight against the world’s toughest diseases. With a focus on Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. As part of the Amgen team, you’ll help make a lasting impact on the lives of patients while advancing your career.

Amgen’s newest drug substance manufacturing plant will combine single use technologies with traditional stainless steel equipment, integrating sustainability innovations to reduce carbon and waste in a carbon‑neutral world by 2027.

Oversee the Automation Engineering team, lead technical projects, drive innovation, and support manufacturing’s automation needs. Provide leadership and guidance for 24/7 manufacturing and facility operations, ensuring engineering efforts align with strategic objectives.

• Build and lead a team of automation engineering professionals and serve as the main point of contact for the automation engineering function.
• Support design reviews while partnering closely with corporate engineering.
• Execute and support the commissioning and qualification of process equipment automation in alignment with GMP requirements, working with global engineering during site installation.
• Collaborate with the site process engineering team to understand key process requirements and develop process control automation solutions primarily utilizing Emerson DeltaV Distributed Control System (DCS).
• Support commissioning and qualification efforts, including Automation Installation Verification/Automation Check Out (IV/ACO).
• Partner with various organizational units to support operational readiness tasks, document reviews, deviation investigation and change controls.
• Provide mentoring to develop and accelerate site technical automation capabilities.

• Lead a team of automation engineering professionals and serve as the main point of contact for the automation engineering function.
• Be accountable for automation system administration, operating systems, hot‑fix assessments, rollout, preventative and corrective maintenance, spare‑parts management, and ownership of departmental SOPs.
• Manage day‑to‑day automation support, including 24/7 onsite/on‑call support, troubleshooting, and daily manufacturing and engineering meetings.
• Establish clear expectations and priorities, encourage a culture of continuous improvement, partnership, and knowledge sharing, and provide development opportunities, feedback, and active listening.
• Effectively collaborate with key customers and support groups (Manufacturing, Quality, Process Development, Maintenance, network partners).
• Perform automation change assessments, implement automation system configuration changes, and support engineering and process qualification runs.
• Represent automation in cross‑functional design reviews and audits.
• Seek innovative ways to improve business, reduce costs, and enhance safety, reliability, efficiency, and sustainability.
• Maintain data integrity in accordance with Amgen and industry standards.
• Provide technical support to troubleshoot, identify, and resolve process and system issues.
• Provide strategic, tactical management and leadership to ensure 24/7 day‑to‑day reliability of plant operations.
• Participate in budgeting for automation engineering, including forecasting costs and managing expenditures.
• Travel up to 10% domestic/international.

• High school diploma / GED and 12 years of engineering experience
• Associate’s degree and 10 years of engineering experience
• Bachelor’s degree and 8 years of engineering experience
• Master’s degree and 6 years of engineering experience
• Doctorate degree and 2 years of engineering experience

• In addition to meeting at least one of the above requirements, a minimum of 2 years of experience directly managing people and/or leading teams, projects, programs, or directing allocation of resources is required. Managerial experience may run concurrently…