Site Start-Up and Performance Enabling Lead; Holly Springs

Welcome to Holly Springs, North Carolina—home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing.

The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes.

This is a fast‑paced, entrepreneurial environment with a high level of accountability, with planned launch in 2028.

Are you a problem‑solver and change‑agent who thrives in a team environment, eager to tackle the most complex manufacturing challenges? If so, this is a once‑in‑a‑lifetime opportunity to launch a state‑of‑the‑art facility from the ground‑up and shape the culture of our organization for the next generation.

Join us in Holly Springs, where you won't just build a plant—you will build the future of medicine.

As a member of the Holly Springs Leadership Team, you will report directly to the Vice President/Site Head and spearhead efforts to start‑up and commercialise operations of this green‑field site to enable a 2028 launch. You will manage the PMO office and ensure all strategic programmes to enable operational performance of Holly Springs are delivered on time. You will align the site operation with corporate operating principles, pharma vision and network strategies.

Your immediate focus will be facilitating the successful operational start‑up of the facility with a vision to achieving the long‑term strategic goals for Holly Springs to enable full deployment of new assets and new products to our site. You will work in close collaboration with global leaders in the network, peers in the Holly Springs Leadership Team, and the PT Manufacturing team, and will drive the translation of network plans to the site level and vice versa.

You will gain a deep understanding of long‑term business needs, identifying performance gaps, and actively shaping strategic priorities for both people and the broader site strategy and performance indicators. In this newly established role, you will provide a distinctive opportunity to actively integrate our culture initiatives, performance improvement activities, and overall site strategy. Your primary focus will involve leading the development and implementation of management strategies and goals, driving operational performance improvement at Holly Springs, and actively contributing to the broader site strategy.

• Lead and coordinate operational start‑up of the facility, coordinating multiple operational work streams.
• Lead the Project Management Office for key performance enabling projects at Holly Springs.
• Act as a crucial thought partner to the Site Head and Site Leadership Team.
• Take the lead in the development and execution of comprehensive strategies, along with corresponding goals and KPIs, spanning the different departments and portfolio.
• Ensure site alignment with key stakeholders across the Roche network and local North Carolina partners.
• Partner with site and network people‑and‑culture leaders to drive site workforce strategy to enable full deployment of new assets and new products to our site.
• Lead complex and cross‑functional initiatives across the site in a timely and effective manner.
• Serve as the primary site contact for network strategy planning and deployment activities.
• Lead cross‑functional projects integral to the development and implementation of the Holly Springs site strategy.
• Support efforts to cultivate an environment that makes Genentech/Roche and the site a great place to work; actively shape organisational operating models.
• Collaborate across a broad set of stakeholders, spanning all sites in the network and integrating Holly Springs with the PT network.
• Articulate our…