Sr. Principal Automation Engineer – Oligonucleotide

Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees worldwide work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and seek individuals determined to make life better for others.

Lilly is currently constructing an advanced manufacturing facility for production of API molecules located in Houston, TX. This facility will provide APIs for current and future products, including new modalities. This is a unique opportunity to be part of the site technical team for the startup of a greenfield manufacturing site. The successful candidate will help build the organization, the facility, and the culture to enable a successful startup into GMP manufacturing operations.

• Lead the design and delivery of the Delta
  
  V platform and associated software integration teams as part of Lilly’s manufacturing expansion.
• Direct one or more project work streams for the automation DCS function including design, scheduling, staffing, and qualification in the Drug Substance (Active Pharmaceutical Ingredient) network.
• During design and startup (expected 2029 to 2030), integrate with the corporate delivery team leading work streams on design, delivery, and startup of drug substance manufacturing focusing on Oligonucleotide.
• Collaborate with A&E firms, system integrators, corporate and site engineering peers, and Tech@Lilly to develop and manage the Delta
  
  V DCS system and software design, testing, startup, and qualification.
• Be a site-based member closely integrated with Lilly’s Corporate Automation Team GPACE, providing automation, measurement, and process control solutions and supporting training, standards, and capital project delivery.
• Post-project delivery, support GMP manufacturing operations in small molecule or oligonucleotides with significant collaboration, creativity, and resilience as the site grows to full-scale GMP manufacturing through startup.
• Provide leadership for safety, mentoring, and applying engineering and automation principles to design and problem solving.
• Develop requirements and specifications with Lilly engineering, A&E firms, and system integrators to form the foundation for software development and system architecture.
• Manage one or more system integrators to fully deliver and test Delta
  
  V software.
• Collaborate with Tech@Lilly to deliver an integrated Automation/MES solution scaled for business needs.
• Participate in basic and detailed design including staffing, statements of work, supplier management, and delivery strategies for automation systems.
• Contribute to developing computer system validation strategies.
• Develop and build capabilities within the Houston site automation team.
• Develop site procedures for automation platforms and related administration activities.
• Provide engineering support for Process Safety Management (PSM) and Process Hazard Reviews (PHRs).
• Provide technical oversight during development of equipment and process system User Requirements and related Design Review/Qualification documentation to ensure equipment and systems are suitable for their intended purpose.

• Bachelor’s degree in engineering or related applicable discipline required.
• 5+ years of experience in Process Automation with experience on the Emerson Delta
  
  V Platform preferred; other platform experience will be considered.
• 5+ years of experience in API/Drug Substance manufacturing preferred; related manufacturing experience will be considered.

Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

• Technical knowledge in process instrumentation.
• Batch control.
• Strong analytical and critical thinking skills.
• Ability to collaborate with others and to influence.
• Technical knowledge on the utilization of data historians.
• Experience with system integration…