Associate Director - Infrastructure Architect

Infrastructure Architect – Tech@Lilly

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Lilly is entering an exciting period of growth, and we are committed to delivering innovative medicines to patients around the world. Lilly is investing in a new state-of-the-art manufacturing site in Houston, Texas. The new facility for API manufacturing of Small Molecule and Oligonucleotides will be built using the latest high-tech equipment, sophisticated highly integrated and automated manufacturing systems, and have a focus on minimizing the impact to our environment.

This is an exciting once-in-a-lifetime opportunity to help build and operate a new site.

You will be part of Technology at Lilly MQ (Manufacturing and Quality), an organization that drives manufacturing operational excellence and productivity efforts through utilization of technology. Technology at Lilly MQ strives to enable the making of medicine "with safety first and quality always".

The Infrastructure Architect will be reporting to the Sr. Director Technology at Lilly for Houston.

As Infrastructure Architect, you will lead the strategy, delivery, and lifecycle management of site IT infrastructure, including business and manufacturing workstations, peripherals, printers, telecommunications, and related systems. You will support Manufacturing Operations, Supply Chain, Quality, Engineering, and Technical Services/Manufacturing Science, serve as the primary site contact for Global Infrastructure Delivery Teams, lead site infrastructure projects, and ensure alignment with Lilly cybersecurity and compliance standards.

Infrastructure & Site Operational Readiness

• Lead the design, deployment, and qualification of site IT/OT infrastructure, ensuring readiness for GMP manufacturing operations across small molecule, oligonucleotide, and warehouse areas.
• Drive site start-up and integration of IT systems including:
  Infrastructure, Manufacturing Execution System (MES), Data Historian and Real Time Floor Tracking, Data Integration and Analytics, Data Integrity, Laboratory Information Management Systems (LIMS), CAPA systems, Enterprise Resource Planning (ERP), Warehouse Management and Logistics, Access Security, Building Monitoring, and Risk Management.
• Monitor datacenter and virtual server environments, ensuring high availability, performance, and preventive maintenance.
• Manage storage, backup, and disaster recovery systems to safeguard data integrity and system resilience.
• Lead the full lifecycle of manufacturing computers, including procurement, qualification, patching, and decommissioning, in compliance with GxP and data integrity standards.
• Ensure network reliability and security across IT and OT environments, coordinating upgrades and troubleshooting activities.
• Collaborate with Automation and Engineering teams to integrate OT systems (DeltaV DCS, process historians) with enterprise IT layers, ensuring secure and reliable data flows aligned to ISA/IEC 62443 and Lilly cybersecurity standards.
• Coordinate with facilities, construction, and vendors to ensure infrastructure is installed, tested, and qualified in step with construction phases (fit-out through C&Q/IV/OV).

• Direct the day-to-day work priorities of a team of Infrastructure Analysts, assigning tasks and sequencing work aligned to project phases, site milestones, and operational needs.
• Serve as the technical point of contact for the analyst team, providing guidance, removing blockers, and ensuring work is executed to the required quality and timeline.
• Adjust workload allocation across the team as site priorities evolve through construction, commissioning, and production ramp phases.

• Ensure all infrastructure designs and implementations comply with Lilly cybersecurity standards, GxP data integrity requirements, and applicable regulatory guidelines (FDA, EMA).
• Maintain compliance with cybersecurity policies, IT standards, and documentation requirements including SOPs, system descriptions, and change control records.

• Oversee IT vendors and service providers to ensure SLA performance and drive continuous infrastructure improvement.
• Develop runbooks, escalation paths, and support models to sustain infrastructure from production ramp-up through steady-state operations.
• Establish monitoring, alerting, and capacity planning processes to meet…