Associate Director - Infrastructure Architect

Infrastructure Architect – Tech@Lilly

We are looking for an experienced Infrastructure Architect to lead the strategy, delivery, and lifecycle management of site IT infrastructure at our new manufacturing facility in Houston, Texas. You will support manufacturing operations, supply chain, quality, engineering, and technical services teams, ensuring alignment with Lilly cybersecurity and compliance standards.

Lead the design, deployment, and qualification of site IT/OT infrastructure; drive start‑up and integration of key systems; monitor datacenter and server environments; manage storage, backup, and disaster recovery; oversee the lifecycle of manufacturing computers; ensure network reliability and security; collaborate with automation and engineering teams; coordinate with facilities, construction, and vendors to align infrastructure with construction phases.

• Lead the design, deployment, and qualification of site IT/OT infrastructure, ensuring readiness for GMP manufacturing operations across small molecule, oligonucleotide, and warehouse areas.
• Drive site start-up and integration of IT systems including Infrastructure, Manufacturing Execution System (MES), Data Historian and Real Time Floor Tracking, Data Integration and Analytics, Data Integrity, Laboratory Information Management Systems (LIMS), CAPA systems, Enterprise Resource Planning (ERP), Warehouse Management and Logistics, Access Security, Building Monitoring, and Risk Management.
• Monitor datacenter and virtual server environments, ensuring high availability, performance, and preventive maintenance.
• Manage storage, backup, and disaster recovery systems to safeguard data integrity and system resilience.
• Lead the full lifecycle of manufacturing computers, including procurement, qualification, patching, and decommissioning, in compliance with GxP and data integrity standards.
• Ensure network reliability and security across IT and OT environments, coordinating upgrades and troubleshooting activities.
• Collaborate with Automation and Engineering teams to integrate OT systems (DeltaV DCS, process historians) with enterprise IT layers, ensuring secure and reliable data flows aligned to ISA/IEC 62443 and Lilly cybersecurity standards.
• Coordinate with facilities, construction, and vendors to ensure infrastructure is installed, tested, and qualified in step with construction phases (fit-out through C&Q/IV/OV).

• Direct the day-to-day work priorities of a team of Infrastructure Analysts, assigning tasks and sequencing work aligned to project phases, site milestones, and operational needs.
• Serve as the technical point of contact for the analyst team, providing guidance, removing blockers, and ensuring work is executed to the required quality and timeline.
• Adjust workload allocation across the team as site priorities evolve through construction, commissioning, and production ramp phases.

• Ensure all infrastructure designs and implementations comply with Lilly cybersecurity standards, GxP data integrity requirements, and applicable regulatory guidelines (FDA, EMA).
• Maintain compliance with cybersecurity policies, IT standards, and documentation requirements including SOPs, system descriptions, and change control records.

• Oversee IT vendors and service providers to ensure SLA performance and drive continuous infrastructure improvement.
• Develop runbooks, escalation paths, and support models to sustain infrastructure from production ramp‑up through steady‑state operations.
• Establish monitoring, alerting, and capacity planning processes to meet manufacturing uptime requirements.
• Partner with local and global teams to define and execute the site IT infrastructure roadmap.
• Evaluate internal and external solutions and adjust plans based on site needs, strategic priorities, and emerging trends.
• Support site and enterprise initiatives focused on digital transformation, modernization, and operational efficiency.
• Maintain a safe work environment.

• Bachelor’s degree in IT, Computer Science, Engineering, or a related technical…